公开(公告)号：US08003098B2

公开(公告)日：2011-08-23

申请号：US12280950

申请日：2007-02-22

申请人： Shuichi Nakatsuru ,  Megumi Yoshikawa ,  Shinichi Hiroshima ,  Yoshiro Kishi ,  Motoki Kuhara ,  Shiyo Nishida ,  Midori Shinohara

发明人： Shuichi Nakatsuru ,  Megumi Yoshikawa ,  Shinichi Hiroshima ,  Yoshiro Kishi ,  Motoki Kuhara ,  Shiyo Nishida ,  Midori Shinohara

IPC分类号： A61K39/00

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/72 ,  C07K2317/732

摘要： The present invention relates to the use of cytoxicity based on the effector function of anti-EphA4 antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-EphA4 antibody as an active ingredient for damaging EphA4-expressing cells using antibody effector function. Since EphA4 is strongly expressed in pancreatic cancer cells, the present invention is particularly useful in pancreatic cancer therapies.

摘要翻译： 本发明涉及基于抗EphA4抗体的效应子功能的细胞毒性的用途。 具体而言，本发明提供了包含抗EphA4抗体作为活性成分的方法和药物组合物，用于使用抗体效应子功能损伤表达EphA4的细胞。 由于EphA4在胰腺癌细胞中强烈表达，本发明特别适用于胰腺癌治疗。