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公开(公告)号:US4481138A
公开(公告)日:1984-11-06
申请号:US400324
申请日:1982-07-21
申请人: Shinro Tachibana , Kengo Araki , Shizuko Ohya , Seiji Yoshida
发明人: Shinro Tachibana , Kengo Araki , Shizuko Ohya , Seiji Yoshida
IPC分类号: C07K7/08 , A61K35/38 , A61K38/00 , A61P25/04 , C07K1/20 , C07K14/575 , C07K14/655 , C07K14/675 , C07C103/52
CPC分类号: C07K14/675 , A61K38/00
摘要: A substance having opiate and analgesic activity is obtained from swine duodenum. The opioid substance of the present invention comprises a heptadecapeptide having the following primary amino acid structure: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln.
摘要翻译: 从十二指肠获得具有鸦片和止痛活性的物质。 本发明的阿片样物质包含具有以下伯氨基酸结构的十七肽:Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn- Gln。
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公开(公告)号:US4551273A
公开(公告)日:1985-11-05
申请号:US575804
申请日:1984-01-31
申请人: Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
发明人: Shinro Tachibana , Shizuko Ohya , Yoshihiro Arakawa , Takahiro Nakazawa , Takeru Kaneko , Masuhiro Ikeda , Kiyomi Yamatsu
IPC分类号: C07K14/655 , A61K38/00 , A61P25/04 , C07C231/02 , C07K7/08 , C07K14/575 , C07K14/665 , C07C103/52
CPC分类号: C07K14/665 , A61K38/00 , Y02P20/55
摘要: A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH.sub.2 (in which D.Ile and D.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each an L-amino acid residue and Me represents a methyl group), which exhibits a remarkable analgesic effect when administered peripherally. A process for the preparation thereof by a solid phase method is also disclosed.
摘要翻译: 具有一级结构的新型肽:N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH2(其中D. Ile和D.Leu分别表示D-Ile和D-Leu残基,氨基酸的其它缩写代表每个L-氨基酸残基,Me表示甲基),其在外周施用时显示出显着的镇痛作用。 还公开了通过固相法制备其方法。
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