公开(公告)号：US20070021360A1

公开(公告)日：2007-01-25

申请号：US10475684

申请日：2002-04-23

申请人： Jonathan Nyce ,  Jonathan Pabalan ,  Douglas Aguilar ,  Shoreh Miller ,  Yukui Li ,  Anthony Sandrasagra ,  Evan Katz ,  Lei Tang ,  Syed Shahabuddin

发明人： Jonathan Nyce ,  Jonathan Pabalan ,  Douglas Aguilar ,  Shoreh Miller ,  Yukui Li ,  Anthony Sandrasagra ,  Evan Katz ,  Lei Tang ,  Syed Shahabuddin

IPC分类号： A61K48/00 ,  A61K31/56

CPC分类号： C12N15/111 ,  A61K31/122 ,  A61K31/7088 ,  A61K45/06 ,  C12N15/113 ,  C12N2310/11 ,  C12N2320/31 ,  A61K2300/00

摘要： A pharmaceutical composition and formulations comprise preventative, prophylactic or therapeutic amounts of an oligo(s) anti-sense to a specific gene(s) or its corresponding mRNA(s), and a glucocorticoid and/or non-glucocorticoid steroid or a ubiquinone or their salts. The agents, composition and formulations are used for treatment of ailments associated with impaired respiration, bronchoconstriction, lung allergy(ies) or inflammation, and abnormal levels of adenosine, adenosine receptors, sensitivity to adenosine, lung surfactant and ubiquinone, such as pulmonary fibrosis, vasoconstriction, inflammation, allergies, allergic rhinitis, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction, COPD, RDS, ARDS, cancer, and others. The present treatment is effectively administered by itself for conditions without known therapies, as a substitute for therapies exhibiting undesirable side effects, or in combination with other treatments, e.g. before, during and after other respiratory system therapies, radiation, chemotherapy, antibody therapy and surgery, among others. Each of the agents of this invention may be administered directly into the respiratory system so that they gain direct access to the lungs, or by other effective routes of administration. A kit comprises a delivery device, the agents and instructions for its use.

摘要翻译： 药物组合物和制剂包含预防性，预防性或治疗量的对特定基因或其相应的mRNA反义的寡核苷酸，以及糖皮质激素和/或非糖皮质激素类固醇或泛醌或 他们的盐 药物，组合物和制剂用于治疗与呼吸受阻，支气管收缩，肺过敏或炎症相关的疾病，以及腺苷，腺苷受体，对腺苷，肺表面活性剂和泛醌的敏感性的异常水平，例如肺纤维化， 血管收缩，炎症，过敏，过敏性鼻炎，哮喘，阻碍呼吸，肺痛，囊性纤维化，支气管收缩，COPD，RDS，ARDS，癌症等。 本治疗本身对于没有已知疗法的病症本身有效地施用，作为表现出不良副作用的治疗的替代物，或与其它治疗组合，例如， 其他呼吸系统治疗，辐射，化疗，抗体治疗和手术之前，之中和之后等。 本发明的每种药剂可以直接施用到呼吸系统中，使得它们直接进入肺部，或通过其它有效的给药途径。 一个套件包括一个送货装置，代理商和使用说明书。