公开(公告)号：US20080044470A1

公开(公告)日：2008-02-21

申请号：US11695848

申请日：2007-04-03

申请人： Hans-Ulrich Petereit ,  Hema Ravishankar ,  Shraddh Bodinge

发明人： Hans-Ulrich Petereit ,  Hema Ravishankar ,  Shraddh Bodinge

IPC分类号： A61K47/08 ,  A61K47/12 ,  A61K9/28 ,  A61K9/48

CPC分类号： A61K9/5078 ,  A61K9/5026

摘要： A pharmaceutical preparation comprising: a) a core with an active ingredient and with an organic acid and/or the salt of an organic acid; and b) a coating which envelops the core and which comprises a polymer content of (meth)acrylate copolymers which have not more than 15% by weight of cationic or anionic groups, and which comprises at least 60% by weight of a (meth)acrylate copolymer which is composed of free-radically polymerized units of 93 to 98% by weight C1- to C4-alkyl esters of acrylic or of methacrylic acid and 7 to 2% by weight (meth)acrylate monomers having a quaternary ammonium group in the alkyl radical, wherein the active ingredient has a solubility in water of at least 10 g/l at 20° C. and the coating comprises silicon dioxide particles having an average particle size in the range from 1 to 50 μm.

摘要翻译： 一种药物制剂，其包含：a）具有活性成分和有机酸和/或有机酸盐的核心; 和b）包封芯的涂层，其包含具有不超过15重量％的阳离子或阴离子基团的（甲基）丙烯酸酯共聚物的聚合物含量，并且其包含至少60重量％的（甲基）丙烯酸酯共聚物， 丙烯酸酯共聚物，其由93至98重量％的C 1〜C 4 - 丙烯酸或甲基丙烯酸的C 4 - 烷基酯的自由基聚合单元和7至 2重量％的在烷基中具有季铵基团的（甲基）丙烯酸酯单体，其中活性成分在20℃下在水中的溶解度至少为10g / l，并​​且涂层包含具有平均值的二氧化硅颗粒 粒径在1〜50μm的范围内。