公开(公告)号：US20070259948A1

公开(公告)日：2007-11-08

申请号：US11498805

申请日：2006-08-04

申请人： Mukund Keshav Gurjar ,  Radhika Dilip Wakharkar ,  Hanumant Bapurao Borate ,  Ramesh Ganesh Kelkar ,  Andiappan Murugan ,  Mohan Anand Chandavarkar ,  Shreerang Vidyadhar Joshi ,  Sharangi Ravindra Vaiude

发明人： Mukund Keshav Gurjar ,  Radhika Dilip Wakharkar ,  Hanumant Bapurao Borate ,  Ramesh Ganesh Kelkar ,  Andiappan Murugan ,  Mohan Anand Chandavarkar ,  Shreerang Vidyadhar Joshi ,  Sharangi Ravindra Vaiude

IPC分类号： A61K31/381 ,  A61K31/341 ,  C07D307/26 ,  C07D317/00 ,  C07D409/02

CPC分类号： C07D307/58 ,  C07D317/30 ,  C07D405/12 ,  C07D409/12

摘要： The present invention relates to compounds of formula (1), its solvates and pharmaceutically acceptable salts having antifungal activity and its pharmaceutical composition comprising an effective amount of compound of formula (1) wherein R is substituted alkyl, alkenyl, aryl, heteroaryl, 2-thienyl, 3-thienyl, halothienyl, haloalkyl, halophenyl, or pyrrolyl; and R1 and R2, each independent of the other, are hydrogen, halogen, or alkoxy. The invention also relates to a process for the preparation of said compounds by contacting the intermediate alcohol, prepared from 1,2-O-isopropylideneglyceraldehyde and substituted phenylacetates, with acid chlorides under appropriate conditions to obtain some of the preferred compounds of the invention.

摘要翻译： 本发明涉及具有抗真菌活性的式（1）化合物，其溶剂合物和药学上可接受的盐，其药物组合物包含有效量的式（1）化合物，其中R是取代的烷基，烯基，芳基，杂芳基， 噻吩基，3-噻吩基，卤代噻吩基，卤代烷基，卤代苯基或吡咯基; 和R 1和R 2各自独立地是氢，卤素或烷氧基。 本发明还涉及一种制备所述化合物的方法，该方法是在适当的条件下使由1,2-碘异丙基甘油醛和取代的苯乙酸酯制备的中间体醇与酰氯接触，以获得本发明的一些优选化合物。

公开(公告)号：US07041830B2

公开(公告)日：2006-05-09

申请号：US10404007

申请日：2003-03-31

申请人： Uttam Ramrao Kalkote ,  Mukund Keshao Gurjar ,  Shreerang Vidyadhar Joshi ,  Suresh Mahadev Kadam ,  Harish Kashinath Mondkar

发明人： Uttam Ramrao Kalkote ,  Mukund Keshao Gurjar ,  Shreerang Vidyadhar Joshi ,  Suresh Mahadev Kadam ,  Harish Kashinath Mondkar

IPC分类号： C07D211/26

CPC分类号： C07D295/135

摘要： The Present invention relates to a process for the preparation of (RS) 3-methyl-1-(2-piperidinyl phenyl) butyl amine of formula 1. (RS) 3-Methyl-1-(2-piperidinyl phenyl butyl amine having formula 1 is an important key intermediate for the synthesis of repaglinide of formula 2 an oral hypoglycemic agent.

摘要翻译： 本发明涉及制备式（1）的（RS）3-甲基-1-（2-哌啶基苯基）丁基胺的方法。（RS）3-甲基-1-（2-哌啶基苯基丁基胺，其具有式 1是口服降血糖药合成式2瑞格列奈的重要关键中间体。

公开(公告)号：US06812363B2

公开(公告)日：2004-11-02

申请号：US10271299

申请日：2002-10-15

申请人： Krishna K. Maheshwari ,  Rayaprolu Kodandarama Sarma ,  Shreerang Vidyadhar Joshi ,  Anup Ramkrishna Barde ,  Rajiv Pandurang Sutar ,  Prasad Vasudeo Ranade

发明人： Krishna K. Maheshwari ,  Rayaprolu Kodandarama Sarma ,  Shreerang Vidyadhar Joshi ,  Anup Ramkrishna Barde ,  Rajiv Pandurang Sutar ,  Prasad Vasudeo Ranade

IPC分类号： C07C22900

CPC分类号： C07C227/36 ,  C07B2200/07 ,  C07C229/36

摘要： A process for preparing racemic mixtures containing nearly equal amounts of stereo isomers of compounds of formula (I), or their salts, by heating an enantiomerically enriched material with thionyl chloride. A required useful enantiomer may thereby be recovered from unwanted mother liquors that would otherwise be otherwise be discarded.

摘要翻译： 通过用亚硫酰氯加热对映异构体富集的物质，制备含有等量的式（I）化合物的立体异构体或其盐的外消旋混合物的方法。因此可以从不需要的母液中回收所需的有用的对映异构体 否则被丢弃。