公开(公告)号：US20070031495A1

公开(公告)日：2007-02-08

申请号：US11455899

申请日：2006-06-19

申请人： Jonathan Eppstein ,  David Enscore ,  Frank Tagliaferri ,  Gaurav Tolia ,  Shulun Chang ,  Alan Smith ,  Yogi Patel ,  Stuart McRae

发明人： Jonathan Eppstein ,  David Enscore ,  Frank Tagliaferri ,  Gaurav Tolia ,  Shulun Chang ,  Alan Smith ,  Yogi Patel ,  Stuart McRae

IPC分类号： A61K9/24

CPC分类号： A61K9/7053 ,  A61K9/0009

摘要： Disclosed is a device for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject. The device comprises a delivery reservoir comprising: i) a non-biodegradable matrix having a bottom surface and defining a plurality of conduits therein the matrix, at least a portion of the plurality of conduits being in communication with the bottom surface; and ii)an undissolved hydrophilic per meant disposed therein at least a portion of the plurality of conduits of the matrix, wherein the hydrophilic per meant can come in contact with subcutaneous fluid from the subject when the bottom surface of the matrix is positioned in fluid communication with the at least one formed pathway. Also disclosed are systems and methods for causing the transdermal flux of a per meant into a subject via at least one formed pathway through a skin layer of the subject.

摘要翻译： 公开了一种用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的装置。 所述装置包括递送贮存器，其包括：i）具有底表面并且在其中限定所述基质中的多个导管的不可生物降解的基质，所述多个导管的至少一部分与所述底表面连通; 和ii）未溶解的亲水剂，其中每个意图在其中设置多个基质管道的至少一部分，其中，当基质的底表面位于流体连通中时，每个意图的亲水剂可以与来自受试者的皮下流体接触 与至少一个形成的途径。 还公开了用于通过穿过受试者的皮肤层的至少一个形成的途径使每个意图的经皮通量引入受试者的系统和方法。