公开(公告)号：US20070027203A1

公开(公告)日：2007-02-01

申请号：US11494362

申请日：2006-07-26

申请人： Ruihuan Chen ,  Simon Mencher ,  Allen Tsao ,  Xiao Mei Liu ,  Longgui Wang

发明人： Ruihuan Chen ,  Simon Mencher ,  Allen Tsao ,  Xiao Mei Liu ,  Longgui Wang

IPC分类号： A61K31/404

CPC分类号： A61K31/404 ,  Y02A50/411 ,  Y02A50/463 ,  A61K2300/00

摘要： The present invention is directed to a method for treating inflammatory arthritis in a mammal. The method typically comprises administering to an animal a therapeutically effective amount of at least one compound selected from indigo, isoindigo, indirubin or derivatives thereof, such as NATURA-α or NATURA. The present invention is further directed to pharmaceutical compositions that include a therapeutically effective amount of at least one compound of the invention, an anti-inflammatory arthritis agent and a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及一种治疗哺乳动物炎症性关节炎的方法。 该方法通常包括向动物施用治疗有效量的至少一种选自靛蓝，异靛蓝，靛玉红或其衍生物的化合物，例如NATURA-α或NATURA。 本发明进一步涉及药物组合物，其包含治疗有效量的至少一种本发明化合物，抗炎性关节炎药物和药学上可接受的载体。

公开(公告)号：US20050154046A1

公开(公告)日：2005-07-14

申请号：US10754547

申请日：2004-01-12

申请人： Longgui Wang ,  Xiao Liu ,  Lian Mo ,  Simon Mencher ,  James McCarron

发明人： Longgui Wang ,  Xiao Liu ,  Lian Mo ,  Simon Mencher ,  James McCarron

IPC分类号： A61K31/404

CPC分类号： A61K31/404 ,  Y02A50/411 ,  Y02A50/463 ,  A61K2300/00

摘要： The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.

公开(公告)号：US20050197381A1

公开(公告)日：2005-09-08

申请号：US11104422

申请日：2005-04-13

申请人： Longgui Wang ,  Xiao Liu ,  Lian Mo ,  Simon Mencher ,  James McCarron

发明人： Longgui Wang ,  Xiao Liu ,  Lian Mo ,  Simon Mencher ,  James McCarron

IPC分类号： A61K31/404 ,  A61K31/7056 ,  A61K38/13

CPC分类号： A61K31/404 ,  A61K31/606 ,  A61K31/7056 ,  A61K45/00 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

摘要： The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of anti-inflammatory cytokines. The method typically comprises administration of one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, such as, Meisoindigo and NATURA. Preferably the pharmaceutical composition comprises one or more compounds selected from isoindigo, indigo, indirubin, or derivatives thereof, an anti-inflammatory agent, and a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及治疗与促炎细胞因子表达相关的炎性相关疾病和/或降低抗炎细胞因子表达的药物组合物和方法。 该方法通常包括施用一种或多种选自异靛蓝，靛蓝，靛玉红或其衍生物的化合物，例如Meisoindigo和NATURA。 优选地，药物组合物包含一种或多种选自异靛蓝，靛蓝，靛玉红或其衍生物，抗炎剂和药学上可接受的载体的化合物。