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公开(公告)号:US20140227291A1
公开(公告)日:2014-08-14
申请号:US13988307
申请日:2011-08-12
申请人: Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giasi , Ulrich Ebert , Chung-Ming Hsieh
发明人: Stefan Barghorn , Heinz Hillen , Andreas Striebinger , Simone Giasi , Ulrich Ebert , Chung-Ming Hsieh
IPC分类号: C07K16/18
CPC分类号: C07K7/06 , A61K39/3955 , C07K16/18 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/41
摘要: The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.
摘要翻译: 本发明涉及淀粉样蛋白-β(A&bgr)结合蛋白。 本发明的抗体对A和Bgr(20-42)球聚体或任何A&bgr具有高亲和力; 形式,其包含球聚体表位。 还提供了制备方法和使用本发明抗体的方法。