公开(公告)号：US20110171661A1

公开(公告)日：2011-07-14

申请号：US13057029

申请日：2008-08-26

申请人： Young Hwa Chung ,  Eun Sil Yu ,  Soo Hyung Ryu ,  Kyu Won Kim ,  Jeong A Kim

发明人： Young Hwa Chung ,  Eun Sil Yu ,  Soo Hyung Ryu ,  Kyu Won Kim ,  Jeong A Kim

IPC分类号： G01N33/53

CPC分类号： G01N33/57438 ,  G01N2800/54

摘要： Provided are a method of diagnosing the recurrence or possibility of recurrence of hepatocellular carcinoma after hepatocellular carcinoma surgery and a method of screening a drug for preventing the recurrence of hepatocellular carcinoma after hepatocellular carcinoma surgery and treating hepatocellular carcinoma. Specifically, the recurrence or possibility of recurrence of hepatocellular carcinoma after hepatocellular carcinoma surgery is diagnosed and a drug for preventing the recurrence of hepatocellular carcinoma after surgery and treating hepatocellular carcinoma is screened, by measuring expression levels of a metastatic tumor antigen 1 or metastasis associated 1 (MTA1) protein in a biological sample taken from a patient in which hepatocellular carcinoma recurs or is likely to recur after hepatocellular carcinoma surgery and comparing the measured expression levels of the MTA1 protein with those of a normal control group.

摘要翻译： 提供一种诊断肝细胞癌手术后肝细胞癌复发或复发可能性的方法，以及筛选肝细胞癌手术治疗肝细胞癌后肝细胞癌复发的药物方法。 具体来说，通过测定转移性肿瘤抗原1或转移相关的表达水平，筛选肝细胞癌手术后肝细胞癌复发或复发的可能性，并筛选用于预防手术后肝细胞癌复发和治疗肝细胞癌的药物 （MTA1）蛋白质，其中肝细胞癌复发或可能在肝细胞癌手术后复发的患者中获取，并比较测量的MTA1蛋白表达水平与正常对照组的表达水平。