公开(公告)号：US20210118525A1

公开(公告)日：2021-04-22

申请号：US17253833

申请日：2019-06-20

Applicant: Jamie Evan Craig ,  The Flinders University of South Australia ,  The Council of the Queensland Institute of Medical Research ,  University of Tasmania ,  Southern Adelaide Local Health Network

Inventor： Jamie Evan Craig ,  Stuart MacGregor ,  Alex William Hewitt

IPC: G16B20/20 ,  G16B25/10 ,  G16B40/00

Abstract: The present disclosure relates to methods and systems for assessing the risk of glaucoma in a subject. In certain embodiments, the present disclosure provide a method of assessing the risk of primary open angle glaucoma in a subject, the method comprises determining a risk score for primary open angle glaucoma in the subject on the basis of the genetic content of the subject at a plurality of selected genetic loci or markers and thereby assessing the risk of primary open angle glaucoma in the subject, wherein the selected genetic loci or markers comprise (i) genetic loci or markers having an association with glaucoma, and/or (ii) genetic loci or markers having an association with increased intraocular pressure, and/or (iii) genetic loci or markers having an association with an increased vertical cup to disk ratio, and/or (iv) genetic loci or markers having an association with a multi-trait test of glaucoma, intraocular pressure and vertical cup to disc ratio. Other embodiments are described.