公开(公告)号：US08231869B2

公开(公告)日：2012-07-31

申请号：US12090782

申请日：2006-10-18

Applicant: Philip Scuderi, Jr. ,  Vikram Arora ,  Jennifer A. Hunt ,  Valery Novokhatny ,  Stephen R. Petteway, Jr.

Inventor： Philip Scuderi, Jr. ,  Vikram Arora ,  Jennifer A. Hunt ,  Valery Novokhatny ,  Stephen R. Petteway, Jr.

IPC: A61K38/48

CPC classification number: C12Y304/21007 ,  A61K38/484 ,  C12N9/6435

Abstract: Methods of using polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided, including methods related to vitrectomy or vitreolysis. The plasmin(ogen) molecule has a single kringel domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.

Abstract translation: 提供使用与重组修饰的纤溶酶（ogen）分子相关的多核苷酸和多肽的方法，包括与玻璃体切割术或玻璃体解分解相关的方法。 纤溶酶原（Ogen）分子具有与天然人纤溶酶原分子中存在的活化位点N末端的单个kringel结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。

公开(公告)号：US20100047228A1

公开(公告)日：2010-02-25

申请号：US12090782

申请日：2006-10-18

Applicant: Philip Scuderi, JR. ,  Vikram Arora ,  Jennifer A. Hunt ,  Valery Novokhatny ,  Stephen R. Petteway, JR.

Inventor： Philip Scuderi, JR. ,  Vikram Arora ,  Jennifer A. Hunt ,  Valery Novokhatny ,  Stephen R. Petteway, JR.

IPC: A61K38/48

CPC classification number: C12Y304/21007 ,  A61K38/484 ,  C12N9/6435

Abstract: Methods of using polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided, including methods related to vitrectomy or vitreolysis. The plasmin(ogen) molecule has a single kringel domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.

Abstract translation: 提供使用与重组修饰的纤溶酶（ogen）分子相关的多核苷酸和多肽的方法，包括与玻璃体切割术或玻璃体解分解相关的方法。 纤溶酶原（Ogen）分子具有与天然人纤溶酶原分子中存在的活化位点N末端的单个kringel结构域，并显示与天然酶相关的赖氨酸结合和显着的酶特征。