公开(公告)号：US5230883A

公开(公告)日：1993-07-27

申请号：US825884

申请日：1992-01-27

Applicant: Steven Kornguth ,  Patrick Turski ,  H. Ian Robins ,  Robert J. Nickles

Inventor： Steven Kornguth ,  Patrick Turski ,  H. Ian Robins ,  Robert J. Nickles

IPC: A61K47/48 ,  A61K49/08 ,  A61K51/06 ,  G01N33/574

CPC classification number: A61K49/146 ,  A61K49/085 ,  A61K51/088 ,  G01N33/574 ,  A61K2123/00 ,  Y10S436/806 ,  Y10S514/836 ,  Y10T436/24

Abstract: Improved methods of selectively localizing, imaging and/or treating tumors, which have a net negative charge, employ novel compositions containing non-immunogenic complexes having a net positive charge in a sterile solution. The complexes contain polylysine, a linking agent bound to less than all of the lysyl groups of the polylysine, and an imaging agent or a chemotherapeutic agent which is also bound to the linking agent.

Abstract translation: 选择性定位，成像和/或治疗具有净负电荷的肿瘤的改进方法使用含有在无菌溶液中具有净正电荷的非免疫原性复合物的新组合物。 复合物含有聚赖氨酸，其结合到少于聚赖氨酸的所有赖氨酰基的连接剂，以及还结合于连接剂的成像剂或化学治疗剂。