公开(公告)号：US5756516A

公开(公告)日：1998-05-26

申请号：US771281

申请日：1996-12-20

申请人： Lee-Tai Liu ,  Mei-Shey Lin ,  Ya-Chuan Lin ,  Su-Chen Yen ,  Hsiao-Jen Chen ,  Hsiang-Ling Huang ,  Chia-Lin Jeff Wang

发明人： Lee-Tai Liu ,  Mei-Shey Lin ,  Ya-Chuan Lin ,  Su-Chen Yen ,  Hsiao-Jen Chen ,  Hsiang-Ling Huang ,  Chia-Lin Jeff Wang

IPC分类号： C07D403/06 ,  C07D521/00 ,  C07D401/00 ,  A01N43/42 ,  C07D217/00 ,  C07D217/18

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D403/06

摘要： The invention relates to compounds of formula (I) ##STR1## wherein R.sup.1 is an optional substituent any position of phenyl ring and is selected from halogen, --NO.sub.2, --NH.sub.2, --OH and --O--CR.sub.1-6 alkyl; --CH.sub.2 R.sup.2 is a substituent at 1- or 3- position of 1,2,3,4-tetrahydroisoquinoline, wherein R.sup.2 is an azole group such as imidazole or triazole; and R.sup.3 is phenyl optionally substituted with one or more halogen, and pharmaceutical salts thereof. The compounds of formula (I) and salts thereof are useful as antifungal agents. The invention also relates to the antifungal pharmaceutical compositions containing the compounds of formula (I), the methods of treating fungal infections using the compounds of formula (I) and the process for preparing the compounds of formula (I).

摘要翻译： 本发明涉及式（I）化合物其中R 1是任选的苯基环的任何位置，并且选自卤素，-NO 2，-NH 2，-OH和-O-CR 1-6烷基; -CH 2 R 2是1,2,3,4-四氢异喹啉的1-或3-位的取代基，其中R 2是咪唑或三唑等唑类; R3是任选被一个或多个卤素取代的苯基，及其药学上可接受的盐。 式（I）的化合物及其盐可用作抗真菌剂。 本发明还涉及含有式（I）化合物的抗真菌药物组合物，使用式（I）化合物治疗真菌感染的方法和制备式（I）化合物的方法。