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公开(公告)号：US06955903B2
公开(公告)日：2005-10-18
申请号：US10001733
申请日：2001-11-02
CPC分类号： A61K9/146 , A61K9/2054 , A61K38/47
摘要： A preblend for making lactase tablets is prepared containing about 1-99% (preferably about 200-60%) by weight lactase and about 1-99% (preferably about 40-80%) by weight microcrystalline cellulose. Lactase used in the preblend may be in combination with up to about 4 parts (preferably about 0.5-2 parts) by weight cutting agent such as sugars, starches, cellulose, and inorganic salts for each part by weight lactase. About 0.5-4% by weight lubricant such as magnesium stearate may be present in the preblend. A preferred preblend contains about 9.6 weight percent lactase and about 90 weight percent microcrystalline cellulose, or about 2000 to about 9000 FCC lactase units and from about 40 to about 80 weight percent microcrystalline cellulose. Another preferred preblend contains about 9.6 weight percent lactase, about 30.0 weight percent microcrystalline cellulose and about 59.4 weight percent mannitol. Each preblend may also contain magnesium stearate. A preferred lactase is from Aspergillus oryzae and the microcrystalline cellulose preferably has an average particle size of about 10-200 μm.
摘要翻译： 制备用于制备乳糖酶片剂的预混物，其含有约1-99重量％（优选约200-60重量％）乳糖酶和约1-99重量％（优选约40-80重量％）微晶纤维素。 在预混物中使用的乳酸酶可以与每份重量份乳糖酶最多约4份（优选约0.5-2份）重量的切割剂如糖，淀粉，纤维素和无机盐组合。 在预混物中可以存在约0.5-4重量％的润滑剂如硬脂酸镁。 优选的预混物包含约9.6重量％的乳糖酶和约90重量％的微晶纤维素，或约2000至约9000个FCC乳糖酶单元和约40至约80重量％的微晶纤维素。 另一种优选的预混物包含约9.6重量％的乳糖酶，约30.0重量％的微晶纤维素和约59.4重量％的甘露糖醇。 每种预混物也可以含有硬脂酸镁。 优选的乳糖酶来自米曲霉，微晶纤维素的平均粒径优选为约10-200μm。
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公开(公告)号：US06660313B2
公开(公告)日：2003-12-09
申请号：US10067078
申请日：2002-02-04
IPC分类号： A23L128
CPC分类号： C12Y302/01108 , A23L29/06 , A23P10/28 , A23V2002/00 , A61K9/2018 , A61K9/2054 , A61K38/47 , A23V2250/6418 , A23V2250/51084
摘要： There is a formulation having improved chemical stability comprising: a) from about 1% to about 20% by weight of a combination of lactase and cutting agent where said combination has from 0 to about 4 parts by weight cutting agent for each part by weight lactase; b) from about 1% to about 98% by weight of microcrystalline cellulose; c) from about 0% to about 97% by weight of mannitol; and d) an effective amount of lubricant to aid compression.
摘要翻译： 具有改进的化学稳定性的制剂，其包含：a）约1重量％至约20重量％的乳糖酶和切割剂的组合，其中所述组合具有0至约4重量份的切割剂，用于每重量份乳糖酶 ; b）约1％至约98％重量的微晶纤维素; c）约0％至约97％重量的甘露糖醇; andd）有效量的润滑剂以辅助压缩。
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公开(公告)号：US06365208B1
公开(公告)日：2002-04-02
申请号：US08943827
申请日：1997-10-03
IPC分类号： A23L128
CPC分类号： C12Y302/01108 , A23L29/06 , A23P10/28 , A23V2002/00 , A61K9/2018 , A61K9/2054 , A61K38/47 , A23V2250/6418 , A23V2250/51084
摘要： There is a formulation having improved chemical stability containing: a) from about 1% to about 20% by weight of a combination of lactase and cutting agent where said combination has from 0 to about 4 parts by weight cutting agent for each part by weight lactase; b) from about 1% to about 98% by weight of microcrystalline cellulose; c) from about 0% to about 97% by weight of mannitol; and d) an effective amount of lubricant to aid compression.
摘要翻译： 具有改进的化学稳定性的制剂，其含有：a）约1％至约20％重量的乳糖酶和切割剂的组合，其中所述组合具有0至约4重量份的切割剂，用于每重量份乳糖酶 ; b）约1％至约98％重量的微晶纤维素; c）约0％至约97％重量的甘露糖醇; andd）有效量的润滑剂以辅助压缩。
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公开(公告)号：US06057139A
公开(公告)日：2000-05-02
申请号：US496824
申请日：1995-06-29
CPC分类号： A61K9/146 , A61K38/47 , A61K9/2054
摘要： A preblend for making lactase tablets is prepared containing about 1-99% (preferably about 20-60%) by weight lactase and about 1-99% (preferably about 40-80%) by weight microcrystalline cellulose. Lactase used in the preblend may be in combination with up to about 4 parts (preferably about 0.5-2 parts) by weight cutting agent such as sugars, starches, cellulose, and inorganic salts for each part by weight lactase. About 0.5-4% by weight lubricant such as magnesium stearate may be present in the preblend. A preferred preblend contains about 9.6 weight percent lactase and about 90 weight percent microcrystalline cellulose. Another preferred preblend contains about 9.6 weight percent lactase, about 30.0 weight percent microcrystalline cellulose and about 59.4 weight percent mannitol. Each preblend may also contain magnesium stearate. A preferred lactase is from Aspergillus oryzae and the microcrystalline cellulose preferably has an average particle size of about 20-200 .mu.m.
摘要翻译： 制备用于制备乳糖酶片剂的预混物，其含有约1-99重量％（优选约20-60重量％）乳糖酶和约1-99重量％（优选约40-80重量％）微晶纤维素。 在预混物中使用的乳酸酶可以与每份重量份乳糖酶最多约4份（优选约0.5-2份）重量的切割剂如糖，淀粉，纤维素和无机盐组合。 在预混物中可以存在约0.5-4重量％的润滑剂如硬脂酸镁。 优选的预混物含有约9.6重量％的乳糖酶和约90重量％的微晶纤维素。 另一种优选的预混物包含约9.6重量％的乳糖酶，约30.0重量％的微晶纤维素和约59.4重量％的甘露糖醇。 每种预混物也可以含有硬脂酸镁。 优选的乳糖酶来自米曲霉，微晶纤维素的平均粒径优选为约20-200μm。
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