公开(公告)号：US20080166776A1

公开(公告)日：2008-07-10

申请号：US11817022

申请日：2006-03-16

申请人： Sang-Jun Sim ,  Sang-Woo Park ,  Sung-Tae Yoon

发明人： Sang-Jun Sim ,  Sang-Woo Park ,  Sung-Tae Yoon

IPC分类号： C12P17/16

CPC分类号： C12P17/181

摘要： The present invention relates to a method that improves productivity of a useful secondary metabolite by eliminating biological by-products effectively during the culture of a useful secondary metabolite-producing microorganism, and more particularly, in order to efficiently eliminate biological by-products formed during the culture of Sorangium cellulosum, the present invention relates to a method for producing epothilones comprising that a cation exchange resin is added to said culture medium or said culture broth is recirculated through a column charged with a cation exchange resin. According to the present invention, the effective elimination of by-products formed during the culture of Sorangium cellulosum enhances growth rate of the microorganism as well as dramatically improves productivity of epothilones, a useful secondary metabolite

摘要翻译： 本发明涉及通过在有用的次生代谢产物微生物的培养期间有效地消除生物副产物来提高有用的次级代谢产物的生产率的方法，更具体地说，为了有效地消除在 本发明涉及一种生产埃坡霉素的方法，包括将阳离子交换树脂加入到所述培养基中，或者所述培养液通过装有阳离子交换树脂的柱再循环。 根据本发明，有效消除在丝兰纤维素培养过程中形成的副产物提高了微生物的生长速率，并且显着地提高了埃坡霉素（一种有用的次级代谢物）的生产率