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    Synergistic pharmaceutical composition for serotonin reuptake inhibition and process of preparation thereof
    1.
    发明授权
    Synergistic pharmaceutical composition for serotonin reuptake inhibition and process of preparation thereof 有权

    公开(公告)号：US09669043B2

    公开(公告)日：2017-06-06

    申请号：US12069766

    申请日：2008-02-12

    申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

    发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC分类号： A61K31/704 ,  A61K31/70 ,  A61K31/702 ,  A61K36/23

    CPC分类号： A61K31/702 ,  A61K36/23

    摘要： The present invention relates to a novel pharmaceutical composition for serotonin reuptake inhibition, wherein the composition comprises pentacyclic terpenoid glycosides, preferably asiaticoside and madecassoside optionally along with excipients. Also the present invention relates to a process of preparation of novel pharmaceutical composition for serotonin reuptake inhibition, wherein the process comprising steps of: (a) obtaining extract from the plant Centella asiatica; (b) treating the extract with the solvents to remove fatty substances, chlorophyll and other colorants; (c) purifying the extract through HPLC to obtain the eluted solvent; and (d) concentrating the eluted solvent to arrive at the composition. The invention also relates to the use of a composition comprising pentacyclic terpenoid glycosides, preferably asiaticoside and madecassoside optionally along with excipients to manufacture a medicament for serotonin reuptake inhibition in a subject in need thereof.

    Botanically derived composition and a process thereof
    2.
    发明授权
    Botanically derived composition and a process thereof 有权
    植物衍生组合物及其制备方法

    公开(公告)号：US08288364B2

    公开(公告)日：2012-10-16

    申请号：US12117967

    申请日：2008-05-09

    申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

    发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC分类号： A61K31/715

    CPC分类号： C07H3/06

    摘要： The present invention relates to a novel botanical compound as provided in structural formula I optionally along with excipients for improving body composition and the factors related to the pre-diabetic and diabetic conditions. It also relates to a process of manufacture of the novel botanical compound for improving body composition and factors related to the pre-diabetic and diabetic conditions. The present invention also relates to the use of the novel botanical compound for improving body composition, reducing body fat, increasing muscle mass, enhancing strength and improving impaired glucose metabolism. The present invention also relates to the use of the novel botanical compound for the improvement of factors related to the pre-diabetic and diabetic conditions.

    摘要翻译： 本发明涉及结构式I中提供的新型植物化合物，任选地与用于改善身体组成的赋形剂以及与糖尿病前期和糖尿病病症相关的因素。 本发明还涉及新型植物化合物的制造方法，其用于改善身体组成和与糖尿病前期和糖尿病状态相关的因素。 本发明还涉及新型植物化合物用于改善身体组成，减少体脂肪，增加肌肉量，增强强度和改善糖代谢障碍的用途。 本发明还涉及新型植物化合物用于改善与糖尿病前期和糖尿病状况有关的因素的用途。

    Synergistic composition for the treatment of diabetes mellitus
    3.
    发明授权
    Synergistic composition for the treatment of diabetes mellitus 有权
    用于治疗糖尿病的协同组合物

    公开(公告)号：US07674485B2

    公开(公告)日：2010-03-09

    申请号：US11355868

    申请日：2006-02-15

    申请人： Sunil Bhaskaran ,  Vishwaraman Mohan

    发明人： Sunil Bhaskaran ,  Vishwaraman Mohan

    IPC分类号： A61K36/48

    CPC分类号： A61K31/195 ,  A61K31/198 ,  A61K31/205 ,  A61K31/56 ,  A61K36/48 ,  Y10S514/866 ,  A61K2300/00

    摘要： A composition for the treatment of diabetes in a subject in need thereof, said composition—comprising Trigonelline of concentration ranging between 20 to 30%, amino acids of concentration ranging between 20 to 60%, and soluble fiber of concentration ranging between 10 to 60%, optionally along with pharmaceutically acceptable additives, a process thereof and also, a method of treating diabetes.

    摘要翻译： 用于治疗有需要的受试者的糖尿病的组合物，所述组合物包含浓度范围为20至30％的浓度范围为20至60％的氨基酸，浓度范围为10至60％的可溶性纤维， ，任选地与药学上可接受的添加剂，其方法以及治疗糖尿病的方法。

    Synergistic composition for the treatment of diabetes mellitus
    4.
    发明授权
    Synergistic composition for the treatment of diabetes mellitus 有权
    用于治疗糖尿病的协同组合物

    公开(公告)号：US07641925B2

    公开(公告)日：2010-01-05

    申请号：US11356274

    申请日：2006-02-15

    申请人： Sunil Bhaskaran ,  Vishwaraman Mohan

    发明人： Sunil Bhaskaran ,  Vishwaraman Mohan

    IPC分类号： A61K36/48 ,  A61P7/12

    CPC分类号： A61K31/195 ,  A61K31/198 ,  A61K31/205 ,  A61K31/56 ,  A61K36/48 ,  Y10S514/866 ,  A61K2300/00

    摘要： A synergistic composition for the treatment of diabetes in a subject in need thereof, comprising Trigonelline of concentration ranging between 20 to 30%, amino acids of concentration ranging between 20 to 60%, and soluble fiber of concentration ranging between 10 to 60%, optionally along with pharmaceutically acceptable additives, a process thereof and also, a method of treating diabetes.

    摘要翻译： 用于治疗有需要的受试者的糖尿病的协同组合物，其包含浓度范围在20至30％之间的浓度范围为20至60％的氨基酸，浓度范围为20至60％的可溶性纤维和10至60％之间的可溶性纤维，任选地 以及药学上可接受的添加剂，其方法以及治疗糖尿病的方法。

    Botanically Derived Composition and a Process Thereof
    5.
    发明申请
    Botanically Derived Composition and a Process Thereof 有权
    植物学组成及其过程

    公开(公告)号：US20090281057A1

    公开(公告)日：2009-11-12

    申请号：US12117967

    申请日：2008-05-09

    申请人： Sunil BHASKARAN ,  Mohan VISHWARAMAN

    发明人： Sunil BHASKARAN ,  Mohan VISHWARAMAN

    IPC分类号： A61K31/702 ,  C07H3/06 ,  A61P3/00

    CPC分类号： C07H3/06

    摘要： The present invention relates to a novel botanical compound as provided in structural formula I optionally along with excipients for improving body composition and the factors related to the pre-diabetic and diabetic conditions. It also relates to a process of manufacture of the novel botanical compound for improving body composition and factors related to the pre-diabetic and diabetic conditions. The present invention also relates to the use of the novel botanical compound for improving body composition, reducing body fat, increasing muscle mass, enhancing strength and improving impaired glucose metabolism. The present invention also relates to the use of the novel botanical compound for the improvement of factors related to the pre-diabetic and diabetic conditions.

    摘要翻译： 本发明涉及结构式I中提供的新型植物化合物，任选地与用于改善身体组成的赋形剂以及与糖尿病前期和糖尿病病症相关的因素。 本发明还涉及新型植物化合物的制造方法，其用于改善身体组成和与糖尿病前期和糖尿病状态相关的因素。 本发明还涉及新型植物化合物用于改善身体组成，减少体脂肪，增加肌肉量，增强强度和改善糖代谢障碍的用途。 本发明还涉及新型植物化合物用于改善与糖尿病前期和糖尿病状况有关的因素的用途。

    METHOD OF MANAGING CHEMOTHERAPY INDUCED ALOPECIA OR CACHEXIA OR BOTH
    8.
    发明申请
    METHOD OF MANAGING CHEMOTHERAPY INDUCED ALOPECIA OR CACHEXIA OR BOTH 有权
    化学疗法诱导的ALOPECIA或CACHEXIA或两种治疗方法

    公开(公告)号：US20140187624A1

    公开(公告)日：2014-07-03

    申请号：US14233510

    申请日：2012-07-17

    申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

    发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC分类号： A61K31/352

    CPC分类号： A61K31/352

    摘要： The present disclosure is related to management of chemotherapy induced side effects namely cachexia and alopecia by administering a pharmaceutical composition comprising pentameric type A procyanidin flavonoid, trimeric procyanidin flavonoid and tetrameric procyanidin flavonoid, optionally along with pharmaceutical excipients.

    摘要翻译： 本公开涉及通过施用包含五聚体A型原花青素类黄酮，三聚原花青素类黄酮和四聚原花青素类黄酮的药物组合物，任选地与药物赋形剂，来管理化疗诱导的副作用，即恶病质和脱发。

    Process for Obtaining Purified Pterostilbene and Methods of Use Thereof
    9.
    发明申请
    Process for Obtaining Purified Pterostilbene and Methods of Use Thereof 有权
    获得纯P il烯的方法及其使用方法

    公开(公告)号：US20110144053A1

    公开(公告)日：2011-06-16

    申请号：US13059042

    申请日：2009-07-30

    申请人： Sunil Bhaskaran ,  Mohan Vishwaraman

    发明人： Sunil Bhaskaran ,  Mohan Vishwaraman

    IPC分类号： A61K31/724 ,  C07C41/36 ,  C07H15/207 ,  C12N9/99 ,  A61P25/00 ,  A61P25/28 ,  A61P25/14 ,  A61P21/00

    CPC分类号： A61K31/09 ,  C07B63/00 ,  C07C41/36 ,  C07C43/23

    摘要： The present invention relates to a process of extraction and purification of a stilbenoid, pterostilbene, from botanical sources. The process involves obtaining pterostilbene having high degree of purity and the present invention also relates to pure form of pterostilbene obtained. The invention also relates to complexing the pterostilbene with carriers such as cyclodextrin for improving its water solubility and bioavailability. The present invention also describes a process for inhibition of Histone Deacetylases using pterostilbene optionally along with a carrier, and a method of managing Poly Glutamine repeat disorders by the administration of pterostilbene optionally along with a carrier.

    摘要翻译： 本发明涉及一种从植物来源提取和纯化芪，蝶啶二烯的方法。 该方法包括获得具有高纯度的芪萜烯，本发明还涉及获得的纯形式的p芪烯。 本发明还涉及使蝶啶与载体例如环糊精络合以改善其水溶性和生物利用度。 本发明还描述了使用任选地与载体一起使用ter il烯抑制组蛋白脱乙酰酶的方法，以及任选地与载体一起施用蝶啶二甲苯来管理聚谷氨酰胺重复紊乱的方法。