公开(公告)号：US20250064969A1

公开(公告)日：2025-02-27

申请号：US18940614

申请日：2024-11-07

Applicant: Suntec Medical, Inc.

Inventor： Chun-Ting Cheng ,  Yuan-Chung Tsai ,  Pauline Ying Lau

IPC: A61K47/69 ,  A61K9/107 ,  A61K47/54 ,  A61K47/60 ,  C07K16/28 ,  C07K16/32

Abstract: The present invention provides a method of treating an autoimmune disease including type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis. multiple sclerosis, systemic lupus erythematosus, psoriasis, myasthenia Gravis, and Hashimoto's thyroiditis. The method comprises the step of administering to a subject in need thereof an effective amount of micelles having an outer shell comprising one or more polymer-flavonoid conjugates, optionally an inner shell comprising one or more flavonoid oligomer, and a drug encapsulated within the shells. The present invention also provides a method of treating an autoimmune disease by administering to a subject in need thereof an effective amount of one or more polymer-flavonoid conjugate or one or more flavonoid oligomers.

公开(公告)号：US20250064972A1

公开(公告)日：2025-02-27

申请号：US18941666

申请日：2024-11-08

Applicant: Suntec Medical, Inc.

Inventor： Chun-Ting Cheng ,  Yuan-Chung Tsai ,  Pauline Ying Lau

IPC: A61K47/69 ,  A61K9/51 ,  A61P35/00 ,  B82Y5/00

Abstract: The present invention provides a conjugate comprising: (a) a cancer-targeting ligand, (b) a hydrophilic polymer of polyethylene glycol (PEG), polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), or dextran, and (c) a flavonoid. The present invention also provides to a micelle nanoparticle composition comprising: (a) an outer shell comprising the conjugate, (b) an inner shell comprising oligomeric (−)-epigallocatechin gallate (OEGCG), and optionally (c) a cancer-treating molecule encapsulated in the inner shell. In one embodiment, the nanoparticle composition has at least 70% of the nanoparticles with a diameter between 20-500 nm or 50-300 nm, and one single major peak in the size distribution. The present invention further provides a method for treating cancer by administering an effective amount of the present nanoparticle composition to a subject. The cancer-targeting ligand targets the tumor and delivers active ingredients to tumor for treating cancer.

公开(公告)号：US20250041218A1

公开(公告)日：2025-02-06

申请号：US18919148

申请日：2024-10-17

Applicant: Suntec Medical, Inc.

Inventor： Chun-Ting Cheng ,  Yuan-Chung Tsai ,  Pauline Ying Lau ,  Kuo-Liang Hou

IPC: A61K9/107 ,  A61K31/704 ,  A61K45/06 ,  A61K47/69 ,  A61P25/28 ,  A61P35/00 ,  C07K16/32

Abstract: The present invention provides a method of preventing or treating CNS diseases. The method comprises the step of administering to a subject in need thereof an effective amount of (i) a polymer-flavonoid conjugate, (ii) a flavonoid oligomer, or (iii) micelles having an outer shell comprising one or more polymer-flavonoid conjugates and optionally an inner shell comprising one or more flavonoid oligomer and a drug encapsulated within the shells. The present method brings therapeutic effective materials through blood-brain barrier to treat CNS diseases. The present method is effective to treat CNS diseases such as brain tumors, stroke, neurodegenerative diseases.

公开(公告)号：US20230263743A1

公开(公告)日：2023-08-24

申请号：US18311114

申请日：2023-05-02

Applicant: Suntec Medical, Inc.

Inventor： Chun-Ting Cheng ,  Cheng-Ying Hsieh ,  Chi-Feng Lin ,  Kuan-Yu Lin ,  Chao-Ming Su ,  Pauline Ying Lau

IPC: A61K9/51 ,  C07K16/32 ,  C07K16/28 ,  C07K16/22 ,  C07K16/18 ,  A61K38/20 ,  A61K38/21 ,  A61K38/19

CPC classification number: A61K9/5146 ,  C07K16/32 ,  C07K16/2881 ,  C07K16/2863 ,  C07K16/22 ,  C07K16/18 ,  A61K38/208 ,  A61K38/2013 ,  A61K38/204 ,  A61K38/2086 ,  A61K38/20 ,  A61K38/212 ,  A61K38/217 ,  A61K38/191 ,  A61K9/5123 ,  A61K9/5192

Abstract: The present invention is directed to nanoparticles comprising: (a) an inner core comprising oligomeric (−)-epigallocatechin gallate (OEGCG), (b) an outer core comprising a polyethylene glycol-epigallocatechin gallate conjugate (PEG-EGCG), and (c) a protein molecule of a drug substance encapsulated in the inner core; wherein at least 70% of the nanoparticles have a diameter between 50-300 nm. The present invention also provides a process for preparing the nanoparticles. The present invention further provides a method of treating cancer by administering to a subject in need thereof the nanoparticles of the present invention, in an amount effective to treat cancer.