公开(公告)号：US11524937B2

公开(公告)日：2022-12-13

申请号：US16594894

申请日：2019-10-07

申请人： CITY OF HOPE ,  THE NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

发明人： Sangkil Nam ,  Richard Jove ,  Leandros Skaltsounis

IPC分类号： C07D209/40 ,  C07D401/14

摘要： Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). Indirubin derivatives (IRDs) potently reduce the viabilities of various cancer cells and affect kinase activities. IRDs disclosed herein provide new therapeutics for cancer and conditions regulated by the kinase activities.

公开(公告)号：US20230174483A1

公开(公告)日：2023-06-08

申请号：US18064874

申请日：2022-12-12

申请人： CITY OF HOPE ,  THE NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

发明人： Sangkil NAM ,  Richard JOVE ,  Leandros SKALTSOUNIS

IPC分类号： C07D209/40 ,  C07D401/14

CPC分类号： C07D209/40 ,  C07D401/14

摘要： Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). Indirubin derivatives (IRDs) potently reduce the viabilities of various cancer cells and affect kinase activities. IRDs disclosed herein provide new therapeutics for cancer and conditions regulated by the kinase activities.

公开(公告)号：US20200247750A1

公开(公告)日：2020-08-06

申请号：US16594894

申请日：2019-10-07

申请人： CITY OF HOPE ,  THE NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

发明人： Sangkil NAM ,  Richard JOVE ,  Leandros SKALTSOUNIS

IPC分类号： C07D209/40 ,  C07D401/14

摘要： Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). Indirubin derivatives (IRDs) potently reduce the viabilities of various cancer cells and affect kinase activities. IRDs disclosed herein provide new therapeutics for cancer and conditions regulated by the kinase activities.

公开(公告)号：US10435367B2

公开(公告)日：2019-10-08

申请号：US13826204

申请日：2013-03-14

申请人： CITY OF HOPE ,  THE NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS

发明人： Sangkil Nam ,  Richard Jove ,  Leandros Skaltsounis

IPC分类号： C07D209/40 ,  C07D401/14

摘要： Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML). Indirubin derivatives (IRDs) potently reduce the viabilities of various cancer cells and affect kinase activities. IRDs disclosed herein provide new therapeutics for cancer and conditions regulated by the kinase activities.