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    TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR
    1.
    发明申请
    TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR 审中-公开
    使用FARNESYL转移酶抑制剂治疗蛋白质

    公开(公告)号：US20100160372A1

    公开(公告)日：2010-06-24

    申请号：US12618265

    申请日：2009-11-13

    申请人： Peter T. Lansbury, JR. ,  Craig J. Justman ,  Tom N. Grammatopoulos ,  Berkley A. Lynch ,  Zhihua Liu

    发明人： Peter T. Lansbury, JR. ,  Craig J. Justman ,  Tom N. Grammatopoulos ,  Berkley A. Lynch ,  Zhihua Liu

    IPC分类号： A61K31/4709 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00 ,  A61P25/28 ,  A61P25/16

    CPC分类号： A61K31/4178 ,  A61K31/4406 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/55 ,  A61K31/5513 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA antagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant.

    摘要翻译： 提供了包含可用于治疗蛋白病的低剂量法呢基转移酶抑制剂的方法和药物组合物。 这些低剂量低于这些化合物最初设计的肿瘤治疗中使用的剂量。 该治疗包括向有需要的受试者施用治疗有效量的法呢基转移酶抑制剂，其中所述量有效地抑制参与自噬途径的非Ras FTase底物的法呢基化，而基本上不影响Ras或其它的法呢基化 肿瘤相关底物。 根据本发明的治疗还可以包括乙酰胆碱酯酶抑制剂，神经营养受体激活剂，NMDA拮抗剂，淀粉样沉积抑制剂，抗精神病药，抗抑郁药，抗焦虑剂或抗氧化剂。

    TREATMENT OF MITOCHONDRIAL DISORDERS USING A FARNESYL TRANSFERASE INHIBITOR
    3.
    发明申请
    TREATMENT OF MITOCHONDRIAL DISORDERS USING A FARNESYL TRANSFERASE INHIBITOR 审中-公开
    使用呋喃葡萄糖转运酶抑制剂治疗麻醉病症

    公开(公告)号：US20100331363A1

    公开(公告)日：2010-12-30

    申请号：US12771221

    申请日：2010-04-30

    申请人： Peter T. Lansbury, JR. ,  Craig J. Justman ,  Tom N. Grammatopoulos ,  Berkley A. Lynch ,  Zhihua Liu

    发明人： Peter T. Lansbury, JR. ,  Craig J. Justman ,  Tom N. Grammatopoulos ,  Berkley A. Lynch ,  Zhihua Liu

    IPC分类号： A61K31/4709 ,  A61P25/00 ,  A61P29/00 ,  A61P9/00

    CPC分类号： A61K31/4709

    摘要： Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject an amount of a farnesyl transferase inhibitor, wherein the amount administered is sufficient to cause an improvement in mitochondrial health in said subject. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant.

    摘要翻译： 提供了包含可用于治疗蛋白病的低剂量法呢基转移酶抑制剂的方法和药物组合物。 这些低剂量低于这些化合物最初设计的肿瘤治疗中使用的剂量。 治疗包括向受试者施用一定量的法呢基转移酶抑制剂，其中施用的量足以导致所述受试者的线粒体健康的改善。 根据本发明的治疗还可以包括乙酰胆碱酯酶抑制剂，神经营养受体的激活剂，NMDA拮抗剂，淀粉样蛋白沉积抑制剂，抗精神病药，抗抑郁药，抗焦虑剂或抗氧化剂。