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公开(公告)号:US08372587B2
公开(公告)日:2013-02-12
申请号:US12937407
申请日:2009-04-14
申请人: Hiroki Nagase , Yui Shinojima , Tadashi Terui
发明人: Hiroki Nagase , Yui Shinojima , Tadashi Terui
CPC分类号: C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要: In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.
摘要翻译: 在本发明中,使用在增殖性疾病中特异性发现的Zar1基因的基因组DNA的甲基化作为标记。 具体地,本发明提供了检测增殖性疾病的方法,其包括检测生物样品中Zar1基因的基因组DNA的甲基化。 由此提供了使用具有高检测率和低假阳性率的标记物来检测增殖性疾病的方法。
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公开(公告)号:US20110033864A1
公开(公告)日:2011-02-10
申请号:US12937407
申请日:2009-04-14
申请人: Hiroki Nagase , Yui Shinojima , Tadashi Terui
发明人: Hiroki Nagase , Yui Shinojima , Tadashi Terui
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6886 , C12Q2600/154 , C12Q2600/156
摘要: In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.
摘要翻译: 在本发明中,使用在增殖性疾病中特异性发现的Zar1基因的基因组DNA的甲基化作为标记。 具体地,本发明提供了检测增殖性疾病的方法,其包括检测生物样品中Zar1基因的基因组DNA的甲基化。 由此提供了使用具有高检测率和低假阳性率的标记物来检测增殖性疾病的方法。
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公开(公告)号:US20080138853A1
公开(公告)日:2008-06-12
申请号:US11987872
申请日:2007-12-05
IPC分类号: G01N1/30
CPC分类号: G01N33/5005 , G01N1/30 , G01N33/5091 , G01N33/56966
摘要: Disclosed is an evaluating method for the properties of a corneocyte in a horny layer sample originating in the skin. In the above method, detected and evaluated are selective staining of a cornified envelope in a corneocyte, selective staining of a nuclear component and the antigenicity.
摘要翻译: 公开了一种来自皮肤的角质层样品中的角质细胞的性质的评价方法。 在上述方法中,检测和评估是在角质细胞中的角质化包膜的选择性染色,核成分的选择性染色和抗原性。
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