公开(公告)号：US5350743A

公开(公告)日：1994-09-27

申请号：US831965

申请日：1992-02-06

申请人： Yoshitaka Ohishi ,  Makoto Tamura ,  Mitsuo Hayashida ,  Satoru Ikegami ,  Yoshiyuki Hiyama ,  Takao Awa ,  Kiyonoshin Ichikawa ,  Kiyoshi Nomiyama ,  Keigo Hanada ,  Mitsuo Mimura

发明人： Yoshitaka Ohishi ,  Makoto Tamura ,  Mitsuo Hayashida ,  Satoru Ikegami ,  Yoshiyuki Hiyama ,  Takao Awa ,  Kiyonoshin Ichikawa ,  Kiyoshi Nomiyama ,  Keigo Hanada ,  Mitsuo Mimura

IPC分类号： C07F9/572 ,  C07F9/576 ,  C07F9/59 ,  C07F9/6558 ,  A61K31/675

CPC分类号： C07F9/5765 ,  C07F9/5721 ,  C07F9/591 ,  C07F9/65583

摘要： A bisphosphonic acid derivative of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein A is ##STR2## each of R.sup.3 and R.sup.4, which may be the same or different, is (i) a hydrogen atom, (ii) a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group, a C.sub.1-6 alkyl-carbonyl group, a C.sub.2-6 alkenyl-carbonyl group, a C.sub.2-6 alkynyl-carbonyl group R.sup.5 and R.sup.6, which may be the same or different, is a hydrogen atom, a hydroxyl group, a halogen atom, a cyano group, a carbamoyl group, an aralkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted amino group, a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group;each of m and n is 0 or a positive integer, provided that (m+n) is from 2 to 5; andR is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.7-15 aralkyl group.

摘要翻译： 式（I）的双膦酸衍生物或其药学上可接受的盐：氨或不同的是（i）氢原子，（ii）C 1-6烷基，C 2-6烯基，C 2-6 炔基，C 1-6烷基 - 羰基，C 2-6烯基羰基，C 2-6炔基 - 羰基R 5和R 6可以相同或不同，为氢原子，羟基， 卤素原子，氰基，氨基甲酰基，芳烷基，取代或未取代的苯基，取代或未取代的氨基，C 1-6烷基，C 2-6烯基，C 2-6炔基 ; m和n分别为0或正整数，条件是（m + n）为2至5; 且R为氢原子，C1-8烷基或C7-15芳烷基。