公开(公告)号：US20130225548A1

公开(公告)日：2013-08-29

申请号：US13881191

申请日：2011-10-27

申请人： Hidetaka Fujihara ,  Hiroyuki Sugiyama ,  Takashi Tsuji ,  Takara Ino ,  Yoshinari Haruta

发明人： Hidetaka Fujihara ,  Hiroyuki Sugiyama ,  Takashi Tsuji ,  Takara Ino ,  Yoshinari Haruta

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D213/84

CPC分类号： C07D401/14 ,  C07D213/84 ,  C07D405/14 ,  C07D417/14

摘要： A main object of the present invention is to provide a novel pyridine derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof. In formula [1], R represents an aryl group or a heteroaryl group, which may be substituted by an optionally substituted alkyl group, a hydroxy group, a halogen atom or a group represented by general formula [2]. In formula [2], -L1-L2-L3-RA   [2] L1 and L3 independently represent a single bond, an alkylene group or a cycloalkylene group; L2 represents a single bond, O, or NRB; RB represents H or an optionally substituted alkyl group; and RA represents B, an amino group, a cyano group, a hydroxy group, an alkoxy group, an aryl group, a monoalkylamino group, a dialkylamino group, a carbamoyl group, an alkyloxycarbonyl group, a monoalkylaminocarbonyl group, a dialkylaminocarbonyl group, an alkylcarbonylamino group, and a saturated heterocyclic group, among other groups.

摘要翻译： 本发明的主要目的是提供由以下通式[1]表示的新型吡啶衍生物或其药学上可接受的盐。 在式[1]中，R表示可被任意取代的烷基，羟基，卤素原子或通式[2]表示的基团取代的芳基或杂芳基。 在式[2]中，-L1-L2-L3-RA [2] L1和L3独立地表示单键，亚烷基或亚环烷基; L2表示单键，O或NRB; RB表示H或任选取代的烷基; RA表示B，氨基，氰基，羟基，烷氧基，芳基，单烷基氨基，二烷基氨基，氨基甲酰基，烷氧基羰基，单烷基氨基羰基，二烷基氨基羰基， 烷基羰基氨基和饱和杂环基等。