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公开(公告)号：US5756675A
公开(公告)日：1998-05-26
申请号：US254419
申请日：1994-06-06
申请人： Yoshikatsu Hirai , Satoru Nakai , Koutoku Aihara , Kazuyoshi Kawai , Mayumi Kaneta , Takashi Kamogashira , Yoshihiro Masui
发明人： Yoshikatsu Hirai , Satoru Nakai , Koutoku Aihara , Kazuyoshi Kawai , Mayumi Kaneta , Takashi Kamogashira , Yoshihiro Masui
IPC分类号： A61K38/00 , C07K14/545 , C07K14/54
CPC分类号： C07K14/545 , A61K38/00
摘要： The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.
摘要翻译： 本发明提供了治疗血小板减少症的药物，其包含至少一种选自IL-1及其衍生物的多肽作为活性成分和具有式（α）的氨基酸序列的II-1α衍生物，其被修饰为 满足至少一项要求：删除16位Arg; 用另一个氨基酸残基取代16位Arg; 将1位Ser序列删除至14位Phe，并将1位Ser的氨基酸序列缺失至15位Met。
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公开(公告)号：US4378348A
公开(公告)日：1983-03-29
申请号：US197103
申请日：1980-09-16
IPC分类号： C07D513/06 , C07D513/16 , A61K35/00
CPC分类号： C07D513/06
摘要： The antibiotic of the invention is produced from a novel strain belonging to Streptomyces hygroscopicus, acts against various bacteria and is useful, for example, as active components of antibacterial compositions.
摘要翻译： PCT No.PCT / JP80 / 00041 Sec。 371日期1980年9月16日 102（e）1980年9月16日PCT PCT。1980年3月8日。本发明的抗生素由属于吸水链霉菌的新型菌株产生，对各种细菌起作用，可用作例如抗菌剂的活性成分 组合物。
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公开(公告)号：US5723117A
公开(公告)日：1998-03-03
申请号：US139862
申请日：1993-10-22
申请人： Satoru Nakai , Seiji Akamatsu , Yoshihiro Masui , Tsutomu Nishida , Takashi Kamogashira , Yoshikatu Hirai
发明人： Satoru Nakai , Seiji Akamatsu , Yoshihiro Masui , Tsutomu Nishida , Takashi Kamogashira , Yoshikatu Hirai
IPC分类号： A61K38/00 , C07K14/545 , A61K38/20
CPC分类号： C07K14/545 , A61K38/00
摘要： A drug for preventing and curing liver diseases comprising at least one member selected from interleukin-1 and its derivatives as an effective component. The drug meaningfully suppresses GOT and GPT activities in blood which are markers of liver diseases, and also suppresses symptoms such as choloplania.
摘要翻译： 一种预防和治疗肝病的药物，其包含选自白介素-1及其衍生物中的至少一种作为有效成分。 该药有意义地抑制作为肝脏疾病标志物的血液中的GOT和GPT活性，并抑制诸如胆红素等症状。
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4.发明授权
公开(公告)号：US5120534A
公开(公告)日：1992-06-09
申请号：US386073
申请日：1989-07-28
申请人： Yoshikatsu Hirai , Satoru Nakai , Koutoku Aihara , Kazuyoshi Kawai , Mayumi Kaneta , Takashi Kamogashira , Yoshihiro Masui
发明人： Yoshikatsu Hirai , Satoru Nakai , Koutoku Aihara , Kazuyoshi Kawai , Mayumi Kaneta , Takashi Kamogashira , Yoshihiro Masui
IPC分类号： A61K38/00 , C07K14/545
CPC分类号： C07K14/545 , A61K38/00
摘要： The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a IL-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.
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公开(公告)号：US4332891A
公开(公告)日：1982-06-01
申请号：US159568
申请日：1980-06-16
IPC分类号： C07D501/57 , C12P35/08
CPC分类号： C12P35/08 , Y10S435/886
摘要： A process for producing an antibiotic Cephamycin C which comprises cultivating a strain of Streptomyces sp. OFR 1022 in a culture medium to accumulate therein Cephamycin C and recovering said Cephamycin C.
摘要翻译： 生产抗生素头孢霉素C的方法，包括培养链霉菌属菌株 OFR 1022在培养基中积聚头孢霉素C并回收所述头孢霉素C.
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