公开(公告)号：US06265577B1

公开(公告)日：2001-07-24

申请号：US09269734

申请日：1999-04-05

申请人： Yasushi Kouno ,  Takenobu Ogata ,  Katsuya Awano ,  Kayoko Matsuzawa ,  Taroh Tooru

发明人： Yasushi Kouno ,  Takenobu Ogata ,  Katsuya Awano ,  Kayoko Matsuzawa ,  Taroh Tooru

IPC分类号： C07D23702

CPC分类号： C07D471/04

摘要： Novel pyrazolopyridylpyridazinone derivatives characterized by being represented by general formula (1) and pharnacologically acceptable salts thereof, which exhibit a phosphodiesterase inhibiting activity and have a selective potent bronchodilating effect on the respiratory tract; a process for the preparation of them; and bronchodilators containing the same as the active ingredient; wherein R1 is C1-C4 lower alkyl or C3-C6 cycloalkyl; and R2, R3, R4 and R5 are each independently hydrogen, C1-C4 lower alkyl or phenyl, or alternatively R3 and R5 may be united to form a double bond.

摘要翻译： 新型吡唑并吡啶酮衍生物，其特征在于由通式（1）表示，其药学上可接受的盐，其表现出磷酸二酯酶抑制活性并对呼吸道具有选择性有效的支气管扩张作用; 它们的制备过程; 和含有与活性成分相同的支气管扩张药; 其中R1是C1-C4低级烷基或C3-C6环烷基; 并且R 2，R 3，R 4和R 5各自独立地为氢，C 1 -C 4低级烷基或苯基，或者R 3和R 5可以一起形成双键。