公开(公告)号：US20120177571A1

公开(公告)日：2012-07-12

申请号：US13387357

申请日：2010-07-28

申请人： Yasuyoshi Watanabe ,  Takeo Sako ,  Koki Hasegawa ,  Yousuke Kanayama ,  Yousuke Kataoka

发明人： Yasuyoshi Watanabe ,  Takeo Sako ,  Koki Hasegawa ,  Yousuke Kanayama ,  Yousuke Kataoka

IPC分类号： A61K51/08 ,  C07K7/56

CPC分类号： A61K51/088 ,  A61K51/083 ,  C07K14/655 ,  G01N33/56966 ,  G01N2333/655

摘要： A pancreatic endocrine cell indicating agent of the present invention includes a modified polypeptide in which a metal chelator binds only to an amino acid that is located at a site other than a somatostatin receptor-binding active site in a polypeptide selected from the group consisting of somatostatin and somatostatin analogs; and a radioactive metal nuclide held by the metal chelator. According to the present invention, it is therefore possible to provide a novel pancreatic endocrine cell indicating agent.

摘要翻译： 本发明的胰内分泌细胞指示剂包括修饰的多肽，其中金属螯合剂仅结合位于除生长抑素受体结合活性位点之外的位点的氨基酸，所述多肽选自生长抑素 和生长抑素类似物; 和由金属螯合剂保持的放射性金属核素。 根据本发明，可以提供一种新型的胰内分泌细胞指示剂。