公开(公告)号：US06274174B1

公开(公告)日：2001-08-14

申请号：US09341052

申请日：1999-06-30

申请人： Takeshi Hom-ma ,  Nagayoshi Myo ,  Takaya Sato ,  Hironobu Nanbu

发明人： Takeshi Hom-ma ,  Nagayoshi Myo ,  Takaya Sato ,  Hironobu Nanbu

IPC分类号： A61K926

CPC分类号： C08L5/04 ,  A61K9/146 ,  A61K9/1652 ,  C08B37/0084

摘要： The present inventors have made studies for the purpose of establishing a process for preparing controlled-release preparations which can rapidly release 99% or more of a slightly soluble medicament (which has by itself shows a slow dissolution rate) in the upper part of the small intestine. As a result, the inventors have succeeded in establishing a process comprising carrying a slightly soluble medicament which has a slow intestinal dissolution rate on aggregates of the spherical microparticles of a multivalent metal alginate, in which each of the secondary particles (i.e., the aggregates) has a specific surface area ranging from 1 to 280 m2/g. This success leads to the accomplishment of the present invention.

摘要翻译： 本发明人为了建立控制释放制剂的方法进行了研究，所述控释制剂可以在小部分的上部快速释放99％以上的微溶药物（其本身显示缓慢的溶解速度） 肠。 结果，本发明人成功地建立了一种方法，其包括携带微溶性药物，其在多价金属藻酸盐的球形微粒的聚集体上具有缓慢的肠溶解速率，其中每个次级颗粒（即聚集体） 具有1至280m 2 / g的比表面积。 这成功地实现了本发明的完成。