公开(公告)号：US20100161301A1

公开(公告)日：2010-06-24

申请号：US12621175

申请日：2009-11-18

申请人： Levon ARAKELYAN ,  Vera Selitser ,  Zvia Agur ,  Tali Eilam Tzoreff

发明人： Levon ARAKELYAN ,  Vera Selitser ,  Zvia Agur ,  Tali Eilam Tzoreff

IPC分类号： G06G7/60

CPC分类号： G06F19/704

摘要： A method for repurposing a pharmaceutical compound. The method includes identifying a pharmaceutical compound, the pharmaceutical compound corresponding to a drug that has failed in clinical development or an approved drug. A mathematical model describing the physiological processes related to at least one disease and the effects of the pharmaceutical compound on the disease is created. The model is adjusted based upon information from preclinical or clinical trials. A new treatment protocol is suggested to salvage the failed drug or a new way to use an approved drug. The suggested treatment protocol is displayed. Systems and computer program products encompassing the above techniques are also disclosed.

摘要翻译： 一种再利用药物化合物的方法。 该方法包括鉴定药物化合物，对应于临床开发失败的药物的药物化合物或批准的药物。 产生描述与至少一种疾病相关的生理过程和药物化合物对疾病的影响的数学模型。 该模型根据临床前或临床试验的信息进行调整。 建议采用新的治疗方案来挽救失败的药物或使用批准药物的新方法。 显示建议的治疗方案。 还公开了包括上述技术的系统和计算机程序产品。

公开(公告)号：US08489336B2

公开(公告)日：2013-07-16

申请号：US12621175

申请日：2009-11-18

申请人： Levon Arakelyan ,  Vera Selitser ,  Zvia Agur ,  Tali Eilam Tzoreff

发明人： Levon Arakelyan ,  Vera Selitser ,  Zvia Agur ,  Tali Eilam Tzoreff

IPC分类号： G06F19/00

CPC分类号： G06F19/704

摘要： A method for repurposing a pharmaceutical compound. The method includes identifying a pharmaceutical compound, the pharmaceutical compound corresponding to a drug that has failed in clinical development or an approved drug. A mathematical model describing the physiological processes related to at least one disease and the effects of the pharmaceutical compound on the disease is created. The model is adjusted based upon information from preclinical or clinical trials. A new treatment protocol is suggested to salvage the failed drug or a new way to use an approved drug. The suggested treatment protocol is displayed. Systems and computer program products encompassing the above techniques are also disclosed.

摘要翻译： 一种再利用药物化合物的方法。 该方法包括鉴定药物化合物，对应于临床开发失败的药物的药物化合物或批准的药物。 产生描述与至少一种疾病相关的生理过程和药物化合物对疾病的影响的数学模型。 该模型根据临床前或临床试验的信息进行调整。 建议采用新的治疗方案来挽救失败的药物或使用批准药物的新方法。 显示建议的治疗方案。 还公开了包括上述技术的系统和计算机程序产品。