公开(公告)号：US20050191348A1

公开(公告)日：2005-09-01

申请号：US10952379

申请日：2005-01-27

Applicant: Moussa Youdim ,  Tamar Amit ,  Orly Weinreb ,  Orit Bar-Am ,  Merav Yogev-Falach

Inventor： Moussa Youdim ,  Tamar Amit ,  Orly Weinreb ,  Orit Bar-Am ,  Merav Yogev-Falach

IPC: A61P9/10 ,  A61K9/20 ,  A61K31/13 ,  A61K31/131 ,  A61K31/135 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  A61P25/30 ,  A61P31/18

CPC classification number: A61K31/13 ,  A61K31/135

Abstract: Propargylamine and pharmaceutically acceptable salts thereof are useful for treating a disease, disorder or condition selected from the group consisting of: (i) a neurodegenerative disease, (ii) a dementia; (iii) an affective or mood disorder; (iv) drug use and dependence; (v) a memory loss disorder; (vi) an acute neurological traumatic disorder or neurotrauma; (vii) a demyelinating disease; (viii) a seizure disorder; (ix) a cerebrovascular disorder; (x) a behavior disorder; and (xi) a neurotoxic injury.

Abstract translation: 炔丙胺及其药学上可接受的盐可用于治疗选自以下的疾病，病症或病症：（i）神经变性疾病，（ii）痴呆; （iii）情感或情绪障碍; （iv）吸毒和依赖; （v）记忆丧失障碍; （vi）急性神经损伤或神经损伤; （vii）脱髓鞘疾病; （viii）缉获障碍; （ix）脑血管障碍; （x）行为障碍; 和（xi）神经毒性损伤。

公开(公告)号：US20110098262A1

公开(公告)日：2011-04-28

申请号：US12865793

申请日：2009-02-01

Applicant: Moussa B.H. Yondim ,  Silvia Mandel ,  Tamar Amit ,  Orit Bar-Am ,  Lana Kupershmidt ,  Zeev Gross ,  Atif Mahammed ,  Irena Saltsman ,  Zoya Okun

Inventor： Moussa B.H. Yondim ,  Silvia Mandel ,  Tamar Amit ,  Orit Bar-Am ,  Lana Kupershmidt ,  Zeev Gross ,  Atif Mahammed ,  Irena Saltsman ,  Zoya Okun

IPC: A61K31/555 ,  A61P25/00 ,  C07F15/00 ,  C07D487/22 ,  A61P3/10

CPC classification number: A61K31/555 ,  A61K31/00 ,  A61K31/409 ,  C07D487/22

Abstract: Transition metal complexes of amphiphilic corroles, optical isomers and pharmaceutically acceptable salts thereof are useful for neuroprotection and neurorescue, particularly for treatment of diabetes and neurodegenerative diseases. The amphiphilic corrole is preferably a 5,10,15-tris-aryl- or 5,10,15-tris-CF3-corrole, and said transition metal complex more preferably has the formula I defined in the specification. Also provided are propargyl-containing corroles carrying one or more radicals substituted by a propargylamino group or one or more nitrogen-containing heteroaryl radicals substituted by propargyl at the ring N atom.

Abstract translation: 两亲性腐蚀物的过渡金属络合物，光学异构体和其药学上可接受的盐可用于神经保护和神经保护，特别是用于治疗糖尿病和神经变性疾病。 两亲性糠醛优选为5,10,15-三 - 芳基 - 或5,10,15-三 - 三氟甲基 - 三氟甲基 - 糠醛，所述过渡金属配合物更优选具有本说明书中定义的式Ⅰ。 还提供了携带一个或多个被炔丙基氨基取代的基团或一个或多个在环N原子上被炔丙基取代的含氮杂芳基的炔基的冠状物。