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公开(公告)号：US06225353B1
公开(公告)日：2001-05-01
申请号：US09189698
申请日：1998-11-10
IPC分类号： A61K3121
CPC分类号： A61K31/15 , A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/56 , A61K36/185 , A61K36/725
摘要： A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.
摘要翻译： 公开了预防或抑制肿瘤生长和治疗恶性黑色素瘤的组合物和方法，没有毒副作用。 桦木酸或桦木酸衍生物是组合物的活性化合物，其局部施用于肿瘤部位。
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公开(公告)号：US5869535A
公开(公告)日：1999-02-09
申请号：US858011
申请日：1997-05-16
IPC分类号： A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/15 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/21 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/56 , A61K36/00 , A61K36/185 , A61K36/725 , A61P35/00 , C07J53/00 , C07J63/00
CPC分类号： A61K31/15 , A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/56 , A61K36/185 , A61K36/725
摘要： A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.
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公开(公告)号：US06495600B1
公开(公告)日：2002-12-17
申请号：US09635385
申请日：2000-08-09
IPC分类号： A61K31195
CPC分类号： A61K31/15 , A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/56 , A61K36/185 , A61K36/725
摘要： A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.
摘要翻译： 公开了预防或抑制肿瘤生长和治疗恶性黑色素瘤的组合物和方法，没有毒副作用。 桦木酸或桦木酸衍生物是组合物的活性化合物，其局部施用于肿瘤部位。
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公开(公告)号：US5962527A
公开(公告)日：1999-10-05
申请号：US857413
申请日：1997-05-16
申请人： John M. Pezzuto , Tapas K. DasGupta , Mary Lou Schmidt , Konrad Marc Kuzmanoff , Lydia Ling-Indeck , Darrick S. H. L. Kim
发明人： John M. Pezzuto , Tapas K. DasGupta , Mary Lou Schmidt , Konrad Marc Kuzmanoff , Lydia Ling-Indeck , Darrick S. H. L. Kim
IPC分类号： A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/15 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/21 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/56 , A61K36/00 , A61K36/185 , A61K36/725 , A61P35/00 , C07J53/00 , C07J63/00 , A61K31/20
CPC分类号： A61K31/235 , A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/15 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/56 , A61K36/185 , A61K36/725
摘要： A composition and method of preventing or inhibiting tumor growth, and of treating malignant cancers without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition.
摘要翻译： 公开了预防或抑制肿瘤生长和治疗无毒副作用的恶性肿瘤的组合物和方法。 桦木酸或桦木酸衍生物是组合物的活性化合物。
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5.发明授权Method and composition for selectively inhibiting melanoma using betalinic acid 失效用槟榔酸选择性抑制黑色素瘤的方法和组成
公开(公告)号：US5658947A
公开(公告)日：1997-08-19
申请号：US407756
申请日：1995-03-21
申请人： Tapas K. DasGupta , John M. Pezzuto
发明人： Tapas K. DasGupta , John M. Pezzuto
IPC分类号： A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/15 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/21 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/56 , A61K36/00 , A61K36/185 , A61K36/725 , A61P35/00 , C07J53/00 , C07J63/00 , A61K31/22
CPC分类号： A61K31/56 , A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/15 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/235 , A61K36/185 , A61K36/725
摘要： A composition and method of inhibiting tumor growth and treating malignant melanoma without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor. Betulinic acid is obtained by the steps of preparing an extract from the stem bark of Ziziphus mauritiana to mediate selective cytotoxic profile against human melanoma in the subject panel of human cancer cell lines, conducting a bioassay-directed fractionation based on the profile of biological activity using cultured human melanoma cells as the monitor, and obtaining betulinic acid.
摘要翻译： 公开了抑制肿瘤生长和治疗恶性黑素瘤而没有毒副作用的组合物和方法。 桦木酸或桦木酸衍生物是组合物的活性化合物，其局部施用于肿瘤部位。 通过以下步骤获得桦木酸，该步骤是从茜草枣的茎皮制备提取物，以介导人癌细胞系受试者小组中针对人黑素瘤的选择性细胞毒性谱，基于生物活性分布进行生物测定分级 培养人黑素瘤细胞作为监测器，并获得桦木酸。
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公开(公告)号：US07414042B2
公开(公告)日：2008-08-19
申请号：US10317361
申请日：2002-12-12
IPC分类号： A61K31/56 , A61K31/15 , A61K31/19 , A61K31/196
CPC分类号： A61K31/15 , A61K31/045 , A61K31/047 , A61K31/075 , A61K31/122 , A61K31/133 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/235 , A61K31/56 , A61K36/185 , A61K36/725
摘要： Compositions and methods are disclosed for treating melanoma wherein a betulinic acid derivative is the active compound in the composition to be administered. The compositions are optionally applied topically is inserted therefor.
摘要翻译： 公开了用于治疗黑色素瘤的组合物和方法，其中桦木酸衍生物是待施用组合物中的活性化合物。 组合物任选地局部施用。
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