公开(公告)号：US4048297A

公开(公告)日：1977-09-13

申请号：US642036

申请日：1975-12-18

Applicant: Raymond E. Counsell ,  Terry Ta-Jen Yu

Inventor： Raymond E. Counsell ,  Terry Ta-Jen Yu

IPC: G01T1/161 ,  A61K29/00 ,  A61K43/00 ,  C07C87/30

CPC classification number: C07D451/02

Abstract: Para-iodobenzyltrimethylammonium iodide is useful as an intermediate in the manufacture of the corresponding compounds wherein the para-iodo atom is enriched with an .sup.123 iodine, .sup.125 iodine or .sup.131 iodine isotope. These radio-iodinated derivatives are valuable adrenal scanning agents in consequence of their propensity to localize in the adrenal gland. Moreover, their ability to bind to catecholamine storage sites accounts for their ability to localize in tissue having a large supply of adrenergic nerves such as spleen and sympathetic ganglia. When injected directly into the cerebrospinal fluid, they concentrate in the choroid plexus and in adrenergic innervated tissues such as the substantia nigra.

Abstract translation: 对碘碘苄基三甲基铵碘化物可用作制备相应化合物的中间体，其中对碘碘原子富含123碘，125碘或131碘同位素。 这些放射碘化衍生物是有价值的肾上腺扫描剂，因为它们倾向于在肾上腺中定位。 此外，它们与儿茶酚胺存储位点结合的能力可以解释其在具有大量肾上腺素能神经如脾脏和交感神经节的组织中的定位能力。 当直接注射到脑脊液中时，它们集中在脉络丛和肾上腺素支配的组织如黑质中。