公开(公告)号：US07045516B1

公开(公告)日：2006-05-16

申请号：US09856372

申请日：1999-11-19

申请人： Sojiro Shiokawa ,  Yasuo Sato ,  Masaaki Izumi ,  Satoshi Yoshida ,  Tomoko Ito ,  Tetsutaro Niisato ,  Hiroshi Murakami

发明人： Sojiro Shiokawa ,  Yasuo Sato ,  Masaaki Izumi ,  Satoshi Yoshida ,  Tomoko Ito ,  Tetsutaro Niisato ,  Hiroshi Murakami

IPC分类号： A61P1/00 ,  A61K31/55 ,  C07D243/08

CPC分类号： C07D413/04 ,  Y02P20/55

摘要： A compound represented by the following general formula (1): wherein R1 represents a halogen atom, R2 represents hydrogen atom or a lower alkyl group, and R3 represents hydrogen atom, a lower alkyl group, a lower alkoxyl group, a hydroxy lower alkyl group, a halogen atom, or a substituted or unsubstituted amino group, wherein a substituent on the amino group is selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkylcarbonyl group, and an amino protective group, or a salt thereof. The compound of the present invention or a salt thereof is useful as an active ingredient of medicaments for preventive and/or therapeutic treatment of conditions of irritable bowel syndrome and digestive tract functional disorder, or condition of diarrhea.

摘要翻译： 由以下通式（1）表示的化合物：其中R 1表示卤素原子，R 2表示氢原子或低级烷基，R“ 3表示氢原子，低级烷基，低级烷氧基，羟基低级烷基，卤素原子或取代或未取代的氨基，其中氨基上的取代基选自 的低级烷基，低级烯基，低级烷基羰基和氨基保护基，或其盐。 本发明的化合物或其盐可用作预防和/或治疗肠易激综合征，消化道功能紊乱或腹泻状况的药物的活性成分。