公开(公告)号：US20200239541A1

公开(公告)日：2020-07-30

申请号：US16774567

申请日：2020-01-28

申请人： Xyphos Biosciences Inc. ,  The J. David Gladstone Institutes, A Testamentary Trust Established Under the Will of J. David Glast

发明人： Kaman KIM ,  Nigel KILLEEN ,  Eytan HERZIG ,  Warner GREENE

IPC分类号： C07K14/705 ,  C07K16/10 ,  C07K14/16

摘要： This application relates generally to the production of modified, non-natural α1-α2 domains of NKG2D ligands with attached polypeptides having specific target-binding properties, for example, antibodies or variable fragments of antibodies, that are selectively delivered to Chimeric Antigen Receptors (CARs) comprised of modified, non-natural NKG2D receptors on engineered mammalian cells. The targeting of surface-expressed molecules includes those of virus-infected cells that can then be attacked and ablated by engineered cells of the immunity system expressing CARs cognate to the modified, non-natural α1-α2 domains of NKG2D ligands with attached polypeptides.

公开(公告)号：US20220243173A1

公开(公告)日：2022-08-04

申请号：US17587116

申请日：2022-01-28

申请人： The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glast

发明人： Mingliang Zhang ,  Sheng Ding

IPC分类号： C12N5/0793 ,  A61K35/30

摘要： Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become neuronal cells.