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公开(公告)号：US20230132035A1
公开(公告)日：2023-04-27
申请号：US17962656
申请日：2022-10-10
发明人： Hang Hubert Yin , Shuting Zhang , Zhenyi Hu
IPC分类号： C07D401/04 , C07D215/20 , A61P19/02 , A61P37/06
摘要： Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
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公开(公告)号：US20230129562A1
公开(公告)日：2023-04-27
申请号：US17959901
申请日：2022-10-04
申请人： University of Maryland, College Park , The Regents of the University of Colorado, a body corporate , Government of the United States of America as Represented by the Secretary of Commerce
IPC分类号： G06N10/20
摘要： A system for quantum state transfer and entanglement generation includes a quantum system including a plurality of qubits, a processor, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the quantum system to: access a signal of the quantum system; encode unknown coefficients in one qubit of the plurality of qubits; initialize each of the remaining qubits of the plurality of qubits in state |0; group the plurality of qubits into a plurality of subsystems; in each of the plurality of subsystems: encode quantum information into Greenberger-Horne-Zeilinger-like (GHZ-like) states using nearest-neighbor interactions; and apply a generalized controlled-phase gate between the plurality of subsystems to merge the GHZ-like states into an entangled state between of the plurality of subsystems.
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公开(公告)号：US20230099219A1
公开(公告)日：2023-03-30
申请号：US18076195
申请日：2022-12-06
发明人： Malik Y. Kahook
IPC分类号： A61F9/007 , A61B17/3211 , A61B17/32
摘要： A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.
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公开(公告)号：US11602556B2
公开(公告)日：2023-03-14
申请号：US16451188
申请日：2019-06-25
发明人： Aaron Michels , Peter A. Gottlieb
摘要： Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to a autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.
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公开(公告)号：US20230073594A1
公开(公告)日：2023-03-09
申请号：US17822175
申请日：2022-08-25
摘要： Methods of inducing a regulatory T cell (Treg) phenotype and skewing naïve T cells toward a pro-regulatory phenotype are disclosed.
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公开(公告)号：US20230070273A1
公开(公告)日：2023-03-09
申请号：US18052751
申请日：2022-11-04
申请人： Alliance for Sustainable Energy, LLC , The Regents of the University of Colorado, a body corporate
IPC分类号： H02S50/10 , G01R31/265
摘要： The present disclosure relates to a steady-state microwave conductivity method that includes modulating a light beam to form an amplitude modulated light having a modulation frequency ω1, producing a microwave waveform, exposing a sample to the amplitude modulated light and a first portion of the microwave waveform to produce an amplitude modulation signal on the first portion of the microwave waveform, and mixing a second portion of the microwave waveform and the amplitude modulation signal to produce a first signal and a second signal.
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公开(公告)号：US20230039591A1
公开(公告)日：2023-02-09
申请号：US17713891
申请日：2022-04-05
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , Travere Therapeutics Switzerland GmbH
摘要： The present invention provides a method of PEGylating a human truncated cystathionine β-synthase protein containing a mutation of a cysteine to a serine at amino acid position 15 (htCBS C15S). The htCBS C15S was PEGylated with one of 5 kDa, 10 kDa, or 20 kDa NHS ester PEG molecules. In-process monitoring of the PEGylation process was used in the method to reduce levels of unPEGylated htCBS C15S and htCBS C15S with insufficient PEGylation. Administration of the PEGylated htCBS C15S had efficacy throughout the course of treatment for homocystinuria.
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公开(公告)号：US20230020244A1
公开(公告)日：2023-01-19
申请号：US17947001
申请日：2022-09-16
IPC分类号： A61F2/16
摘要： An ophthalmic implant including an IOL with haptics, and drug delivery devices secured to the haptics. The posterior-most extent of the drug delivery device is located anterior to the posterior edge or PCE barrier edge, of the IOL. In other configurations, the drug delivery devices are provided with PCO barrier edges.
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公开(公告)号：US20230020167A1
公开(公告)日：2023-01-19
申请号：US17954631
申请日：2022-09-28
IPC分类号： A61F2/14
摘要： This disclosure provides ophthalmic implants such as sulcus implants which can comprise one or more drug delivery devices. Further provided herein are methods of using the drug delivery ophthalmic devices described herein for implantation into a subject's eye, e.g., into an eye's ciliary sulcus or capsular bag.
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公开(公告)号：US11555873B2
公开(公告)日：2023-01-17
申请号：US17166594
申请日：2021-02-03
发明人： Vladislav Gerginov
IPC分类号： G01R33/26 , G01R33/032 , G01R33/00 , A61B5/245
摘要： The disclosure describes optically pumped magnetometers and systems incorporating, and methods of operating, the same. An optically pumped magnetometer according to one embodiment of the present technology includes a vapor cell configured to contain an atomic absorber such as rubidium-87, and at least one light source in optical communication with the vapor cell. The optically pumped magnetometer includes components positioned and configured to provide a bias field, and induce a zeroing field, within the vapor cell. Among other useful and advantageous ends, embodiments of the present technology provide for increasing the degree of atomic polarization in optically pumped magnetometers based on zeroing the bias magnetic field during the optical pumping process.
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