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1.发明申请FLUOROQUINOLONE DERIVATIVES OR SULFONAMIDE MOIETY-CONTAINING COMPOUNDS AS INHIBITORS OF TYROSYL-DNAPHOSPHODIESTERASE (TDP1) 有权氟代喹啉酮衍生物或磺酰胺含有化合物作为酪氨酸 - 磷酸二酯酶（TDP1）的抑制剂公开(公告)号：US20120172371A1
公开(公告)日：2012-07-05
申请号：US13283282
申请日：2011-10-27
申请人： Yves Pommier , Christophe Marchand , Periyasamy Selvam , Thomas Dexheimer , Kasthuraiah Maddali
发明人： Yves Pommier , Christophe Marchand , Periyasamy Selvam , Thomas Dexheimer , Kasthuraiah Maddali
IPC分类号： A61K31/506 , A61P35/00 , C12N9/99 , A61K31/496
CPC分类号： C12N9/99 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K45/06 , C12Y301/04 , A61K2300/00
摘要： A method for treating cancer in a subject, comprising administering to a subject having cancer a therapeutically effective amount of (i) a fluoroquinolone derivative that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity or (ii) a sulfonamide moiety-containing compound that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity, thereby treating the cancer in the subject. In certain embodiments, the fluoroquinolone derivative or sulfonamide moiety-containing compound is co-administered with a topoisomerase I (TopI) inhibitor.
摘要翻译： 一种用于治疗受试者中的癌症的方法，其包括向患有癌症的受试者施用治疗有效量的（i）抑制酪氨酰-DNA-磷酸二酯酶1（Tdp1）活性的氟喹诺酮衍生物或（ii）含磺酰胺部分的化合物， 抑制酪氨酰基-DNA-磷酸二酯酶1（Tdp1）活性，从而治疗受试者的癌症。 在某些实施方案中，含氟喹诺酮衍生物或磺酰胺部分的化合物与拓扑异构酶I（TopI）抑制剂共同施用。
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2.发明授权Fluoroquinolone derivatives or sulfonamide moiety-containing compounds as inhibitors of tyrosyl-dnaphosphodiesterase (TDP1) 有权氟喹诺酮衍生物或含磺酰胺部分的化合物作为酪氨酰 - 非磷酸二酯酶抑制剂（TDP1）公开(公告)号：US08716295B2
公开(公告)日：2014-05-06
申请号：US13283282
申请日：2011-10-27
申请人： Yves Pommier , Christophe Marchand , Periyasamy Selvam , Thomas Dexheimer , Kasthuraiah Maddali
发明人： Yves Pommier , Christophe Marchand , Periyasamy Selvam , Thomas Dexheimer , Kasthuraiah Maddali
IPC分类号： A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K45/06 , C12N9/99
CPC分类号： C12N9/99 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K45/06 , C12Y301/04 , A61K2300/00
摘要： A method for treating cancer in a subject, comprising administering to a subject having cancer a therapeutically effective amount of (i) a fluoroquinolone derivative that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity or (ii) a sulfonamide moiety-containing compound that inhibits tyrosyl-DNA-phosphodiesterase 1 (Tdp1) activity, thereby treating the cancer in the subject. In certain embodiments, the fluoroquinolone derivative or sulfonamide moiety-containing compound is co-administered with a topoisomerase I (TopI) inhibitor.
摘要翻译： 一种用于治疗受试者中的癌症的方法，其包括向患有癌症的受试者施用治疗有效量的（i）抑制酪氨酰-DNA-磷酸二酯酶1（Tdp1）活性的氟喹诺酮衍生物或（ii）含磺酰胺部分的化合物， 抑制酪氨酰基-DNA-磷酸二酯酶1（Tdp1）活性，从而治疗受试者的癌症。 在某些实施方案中，含氟喹诺酮衍生物或磺酰胺部分的化合物与拓扑异构酶I（TopI）抑制剂共同施用。
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