公开(公告)号：US20090117584A1

公开(公告)日：2009-05-07

申请号：US11922990

申请日：2006-06-29

Applicant: Rene Toes ,  Thomas Huizinga ,  Miranda Molenaar ,  Paul Parren ,  Jan Van De Winkel

Inventor： Rene Toes ,  Thomas Huizinga ,  Miranda Molenaar ,  Paul Parren ,  Jan Van De Winkel

IPC: G01N33/53 ,  A01K67/00

CPC classification number: G01N33/5088

Abstract: Use of a non-human mammalian disease model, wherein the non-human mammal has been implanted with human synovial tissue or other human inflamed tissue containing anti-CCP (cyclic citrullinated peptide) antibody producing cells for (i) analyzing cellular processes in a disease associated with anti-CCP antibodies in such human synovial tissue or other human inflamed tissue, (ii) studying the role of anti-CCP antibodies in the induction and progression of a disease associated with anti-CCP antibodies, (iii) testing the efficacy of a therapeutic agent for the prevention or treatment of a disease associated with anti-CCP antibodies, and (iv) identifying a therapeutic agent useful for the prevention or treatment of a disease associated with anti-CCP antibodies. In one embodiment the non-human mammalian disease model is a mouse, such as a SCID mouse, and the disease associated with anti-CCP antibodies is arthritis, such as RA (rheumatoid arthritis).

Abstract translation: 使用非人哺乳动物疾病模型，其中所述非人哺乳动物已经植入人滑膜组织或其它含有抗CCP（环状瓜氨酸化肽）抗体产生细胞的人发炎组织，用于（i）分析疾病中的细胞过程 与所述人滑膜组织或其他人发炎组织中的抗CCP抗体相关，（ii）研究抗CCP抗体在与抗CCP抗体相关的疾病的诱导和进展中的作用，（iii）测试抗CCP抗体 用于预防或治疗与抗CCP抗体相关的疾病的治疗剂，和（iv）鉴定可用于预防或治疗与抗CCP抗体相关的疾病的治疗剂。 在一个实施方案中，非人哺乳动物疾病模型是小鼠，例如SCID小鼠，并且与抗CCP抗体相关的疾病是关节炎，例如RA（类风湿性关节炎）。