公开(公告)号：US20080161361A1

公开(公告)日：2008-07-03

申请号：US11958353

申请日：2007-12-17

Applicant: Jun Wu ,  Ying Luo ,  Tieling Zhou

Inventor： Jun Wu ,  Ying Luo ,  Tieling Zhou

IPC: A61K31/44 ,  A61P43/00

CPC classification number: A61K31/4418 ,  A61K31/704 ,  A61K31/7064 ,  A61N5/10

Abstract: The present invention is directed to a novel use of pyridone derivatives such as pirfenidone for the prevention and treatment of damages to tissues or organs induced by various cytotoxic agents, such as chemotherapeutic agents, biologics, immunosuppressants and radiation. Such prophylactic and/or therapeutic effects of the pyridone derivatives make it possible to increase therapeutic dosages of the cytotoxic agent, thereby enhancing the therapeutic efficacy of the cytotoxic agent and radiation therapy.

Abstract translation: 本发明涉及吡吡酮衍生物如吡非尼酮的新用途，用于预防和治疗由各种细胞毒剂如化学治疗剂，生物制剂，免疫抑制剂和辐射诱导的组织或器官的损伤。 吡啶酮衍生物的这种预防和/或治疗效果使得可以增加细胞毒性剂的治疗剂量，从而增强细胞毒剂和放射治疗的治疗功效。