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1.发明申请ALGINATE OLIGOMERS FOR USE IN OVERCOMING MULTIDRUG RESISTANCE IN BACTERIA 有权在低密度脂蛋白中抑制多重耐药性的ALIGINATE寡聚体公开(公告)号：US20120122768A1
公开(公告)日：2012-05-17
申请号：US13376164
申请日：2010-06-03
IPC分类号： A61K31/734 , A61K31/7052 , A61K31/7048 , A01N43/90 , A01N43/78 , A61P11/06 , A01N43/14 , A01N43/72 , A61P31/04 , A01P1/00 , A61P35/00 , A61P11/00 , A61K38/02 , A01N43/60
CPC分类号： A61K31/734 , A01N37/18 , A01N43/22 , A01N43/60 , A01N43/72 , A01N43/78 , A01N43/86 , A01N43/90 , A61K31/407 , A61K31/427 , A61K31/496 , A61K31/546 , A61K31/65 , A61K31/7028 , A61K31/7048 , A61K31/7052 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer together with the antibiotic. The multidrug resistant bacterium may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with a multidrug resistant bacterium to overcome resistance to the antibiotic in said multidrug resistant bacterium. In another aspect the method can be used to combat contamination of a site with multidrug resistant bacteria, e.g. for disinfection and cleaning purposes.
摘要翻译： 本发明提供一种在多重耐药性细菌中克服对至少一种抗生素的抗性的方法，所述方法包括使所述细菌与抗生素一起与藻酸盐低聚物接触。 多重耐药性细菌可以是生物或无生命的表面，并且提供医疗和非医疗用途和方法。 一方面，本发明提供了一种与至少一种抗生素一起使用的藻酸盐低聚物，用于治疗受多种耐药细菌感染，怀疑感染或有感染风险的受试者，以克服对所述多重耐药细菌中抗生素的抗性 。 在另一方面，该方法可用于抵抗具有多重耐药细菌的位点的污染，例如， 用于消毒和清洁目的。
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公开(公告)号：US20120115803A1
公开(公告)日：2012-05-10
申请号：US13376140
申请日：2010-06-03
IPC分类号： A61K31/7052 , A61K31/715 , A61P41/00 , A61P27/02 , A61P27/16 , A61P1/00 , A61P11/00 , A61P15/00 , A61P21/00 , A61P7/00 , A61P13/12 , A61P13/02 , A61P35/00 , A61P37/02 , A61P31/12 , A61P31/18 , A61P19/02 , A61P3/10 , A61P31/04
CPC分类号： A61K31/734 , A01N37/18 , A01N43/22 , A01N43/60 , A01N43/72 , A01N43/78 , A01N43/86 , A01N43/90 , A61K31/407 , A61K31/427 , A61K31/496 , A61K31/546 , A61K31/65 , A61K31/7028 , A61K31/7048 , A61K31/7052 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The invention provides a method to improve the efficacy of an antibiotic to inhibit the growth of Acinetobacter, said method comprising using said antibiotic together with an alginate oligomer. The Acinetobacter may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with Acinetobacter. In another aspect the method can be used to combat Acinetobacter contamination of a site e.g., for disinfection and cleaning purposes.
摘要翻译： 本发明提供了一种改善抗生素抑制不动杆菌生长的功效的方法，所述方法包括将所述抗生素与藻酸盐低聚物一起使用。 不动杆菌可能在生物或无生命的表面，并提供医疗和非医疗用途和方法。 在一个方面，本发明提供了一种与至少一种抗生素一起使用的藻酸盐低聚物，用不动杆菌治疗受感染，疑似感染或有感染风险的受试者。 在另一方面，该方法可用于抵抗位点的不动杆菌污染物，例如用于消毒和清洁目的。
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公开(公告)号：US08815831B2
公开(公告)日：2014-08-26
申请号：US13376140
申请日：2010-06-03
IPC分类号： A61K31/734 , A61K31/715 , A61K31/7048 , A61K31/7042 , A61K31/7036 , A61P31/00 , A61P31/04
CPC分类号： A61K31/734 , A01N37/18 , A01N43/22 , A01N43/60 , A01N43/72 , A01N43/78 , A01N43/86 , A01N43/90 , A61K31/407 , A61K31/427 , A61K31/496 , A61K31/546 , A61K31/65 , A61K31/7028 , A61K31/7048 , A61K31/7052 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The invention provides a method to improve the efficacy of an antibiotic to inhibit the growth of Acinetobacter, said method comprising using said antibiotic together with an alginate oligomer. The Acinetobacter may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with Acinetobacter. In another aspect the method can be used to combat Acinetobacter contamination of a site e.g., for disinfection and cleaning purposes.
摘要翻译： 本发明提供了一种改善抗生素抑制不动杆菌生长的功效的方法，所述方法包括将所述抗生素与藻酸盐低聚物一起使用。 不动杆菌可能在生物或无生命的表面，并提供医疗和非医疗用途和方法。 在一个方面，本发明提供了一种与至少一种抗生素一起使用的藻酸盐低聚物，用不动杆菌治疗受感染，疑似感染或有感染风险的受试者。 在另一方面，该方法可用于抵抗位点的不动杆菌污染物，例如用于消毒和清洁目的。
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4.发明授权公开(公告)号：US09018158B2
公开(公告)日：2015-04-28
申请号：US13376164
申请日：2010-06-03
IPC分类号： A01N37/18 , A61K38/04 , A61K31/7048 , A61K31/7052 , A61K31/734 , A61K45/06
CPC分类号： A61K31/734 , A01N37/18 , A01N43/22 , A01N43/60 , A01N43/72 , A01N43/78 , A01N43/86 , A01N43/90 , A61K31/407 , A61K31/427 , A61K31/496 , A61K31/546 , A61K31/65 , A61K31/7028 , A61K31/7048 , A61K31/7052 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer together with the antibiotic. The multidrug resistant bacterium may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with a multidrug resistant bacterium to overcome resistance to the antibiotic in said multidrug resistant bacterium. In another aspect the method can be used to combat contamination of a site with multidrug resistant bacteria, e.g. for disinfection and cleaning purposes.
摘要翻译： 本发明提供一种在多重耐药性细菌中克服对至少一种抗生素的抗性的方法，所述方法包括使所述细菌与抗生素一起与藻酸盐低聚物接触。 多重耐药性细菌可以是生物或无生命的表面，并且提供医疗和非医疗用途和方法。 一方面，本发明提供了一种与至少一种抗生素一起使用的藻酸盐低聚物，用于治疗受多种耐药细菌感染，怀疑感染或有感染风险的受试者，以克服对所述多重耐药细菌中抗生素的抗性 。 在另一方面，该方法可用于抵抗具有多重耐药细菌的位点的污染，例如， 用于消毒和清洁目的。
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