公开(公告)号：US20110052787A1

公开(公告)日：2011-03-03

申请号：US12832635

申请日：2010-07-08

申请人： Larry L. Hum ,  James Q. Feng ,  Arienne P. Simon ,  Tolga Tas

发明人： Larry L. Hum ,  James Q. Feng ,  Arienne P. Simon ,  Tolga Tas

IPC分类号： B05D3/00

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/18 ,  C09D5/38 ,  C08L83/04

摘要： A solventless method for forming a coating on a medical electrical lead is described. The method includes combining particles of a therapeutic agent with a polymeric material in a flowable form in the absence of a solvent to form a uniform suspension. A predetermined amount of the suspension is dispensed onto a portion of the lead and is then cured to form the therapeutic agent eluting layer. Additional layers such as a primer layer, fluoro-opaque layer and/or a topcoat layer can be formed using the solventless method. Employing a solventless method may avoid contraction of the layer being formed due to solvent evaporation during the curing process, and may facilitate greater control over the thickness of the therapeutic agent eluting coating.

摘要翻译： 描述了用于在医用电线上形成涂层的无溶剂方法。 该方法包括在不存在溶剂的情况下将治疗剂的颗粒与可流动形式的聚合物材料组合以形成均匀的悬浮液。 将预定量的悬浮液分配到引线的一部分上，然后固化以形成治疗剂洗脱层。 可以使用无溶剂法形成附加层，例如底漆层，氟不透明层和/或顶涂层。 使用无溶剂方法可以避免在固化过程中由于溶剂蒸发而形成的层的收缩，并且可以有助于更好地控制治疗剂洗脱涂层的厚度。

公开(公告)号：US08753708B2

公开(公告)日：2014-06-17

申请号：US12832635

申请日：2010-07-08

申请人： Larry L. Hum ,  James Q. Feng ,  Arienne P. Simon ,  Tolga Tas

发明人： Larry L. Hum ,  James Q. Feng ,  Arienne P. Simon ,  Tolga Tas

IPC分类号： A61L33/00

CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/18 ,  C09D5/38 ,  C08L83/04

摘要： A solventless method for forming a coating on a medical electrical lead is described. The method includes combining particles of a therapeutic agent with a polymeric material in a flowable form in the absence of a solvent to form a uniform suspension. A predetermined amount of the suspension is dispensed onto a portion of the lead and is then cured to form the therapeutic agent eluting layer. Additional layers such as a primer layer, fluoro-opaque layer and/or a topcoat layer can be formed using the solventless method. Employing a solventless method may avoid contraction of the layer being formed due to solvent evaporation during the curing process, and may facilitate greater control over the thickness of the therapeutic agent eluting coating.

摘要翻译： 描述了用于在医用电线上形成涂层的无溶剂方法。 该方法包括在不存在溶剂的情况下将治疗剂的颗粒与可流动形式的聚合物材料组合以形成均匀的悬浮液。 将预定量的悬浮液分配到引线的一部分上，然后固化以形成治疗剂洗脱层。 可以使用无溶剂法形成附加层，例如底漆层，氟不透明层和/或顶涂层。 使用无溶剂方法可以避免在固化过程中由于溶剂蒸发而形成的层的收缩，并且可以有助于更好地控制治疗剂洗脱涂层的厚度。