公开(公告)号：US08389686B2

公开(公告)日：2013-03-05

申请号：US12990897

申请日：2009-05-01

申请人： Mitsuru Akashi ,  Kohji Nishida ,  Michiya Matsusaki ,  Akira Kubota ,  Tomonori Waku

发明人： Mitsuru Akashi ,  Kohji Nishida ,  Michiya Matsusaki ,  Akira Kubota ,  Tomonori Waku

IPC分类号： C07K14/78 ,  A61K38/00

CPC分类号： A61K38/39

摘要： The present invention provides a collagen crosslinking agent superior in biocompatibility that is free from the damage by UV irradiation and also from the problems of toxicity caused by residual monomer or unreacted functional groups. Provided is a noncovalent collagen crosslinking agent (for fibrous protein collagen), comprising a spacer of a polyvalent alcohol having two or more OH groups at the terminals and arms of collagen peptides formed of repetitions of three amino acids, the arms being bound via the OH groups to the spacer.

摘要翻译： 本发明提供一种无生物相容性优异的胶原交联剂，其不受紫外线照射的损伤，也可由残留单体或未反应官能团引起的毒性问题。 提供了一种非共价胶原交联剂（纤维蛋白胶原蛋白），其包含在末端具有两个或更多个OH基团的多元醇的隔离物和由三个氨基酸重复形成的胶原肽的臂，所述臂通过OH结合 组到间隔物。

公开(公告)号：US20110060129A1

公开(公告)日：2011-03-10

申请号：US12990897

申请日：2009-05-01

申请人： Mitsuru Akashi ,  Kohji Nishida ,  Michiya Matsusaki ,  Akira Kubota ,  Tomonori Waku

发明人： Mitsuru Akashi ,  Kohji Nishida ,  Michiya Matsusaki ,  Akira Kubota ,  Tomonori Waku

IPC分类号： C07K14/78

CPC分类号： A61K38/39

摘要： An object of the invention is to provide a collagen crosslinking agent superior in biocompatibility that is free from the damage by UV irradiation and also from the problems of toxicity caused by residual monomer or unreacted functional groups.[Means to Solve] Provided is a noncovalent collagen crosslinking agent (for fibrous protein collagen), comprising a spacer of a polyvalent alcohol having two or more OH groups at the terminals and arms of collagen peptides formed of repetitions of three amino acids, the arms being bound via the OH groups to the spacer.

摘要翻译： 本发明的目的是提供一种无生物相容性优异的胶原交联剂，其不受紫外线照射的损伤，也可由残留单体或未反应官能团引起的毒性问题。 [解决方法]提供了一种非共价胶原交联剂（纤维蛋白胶原蛋白），其包含在末端具有两个或更多个OH基团的多元醇的间隔基和由重复的三个氨基酸形成的胶原肽的臂，臂 通过OH基团结合到间隔基上。