公开(公告)号：US20060236924A1

公开(公告)日：2006-10-26

申请号：US11471545

申请日：2006-06-21

申请人： Nobuo Niimura ,  Yuki Onishi ,  Shigeki Arai ,  Toshiyuki Chatake ,  Mitsuru Maeda ,  Kazuo Kurihara

发明人： Nobuo Niimura ,  Yuki Onishi ,  Shigeki Arai ,  Toshiyuki Chatake ,  Mitsuru Maeda ,  Kazuo Kurihara

IPC分类号： C30B35/00 ,  C30B11/00

CPC分类号： C30B7/00 ,  C30B29/58 ,  Y10T117/10 ,  Y10T117/1012

摘要： A method comprising the steps of continuously changing the concentrations in solution of a biomacromolecule to be crystallized and a precipitant, thereby constructing a crystal phase diagram containing a solubility curve, searching for optimum conditions of crystallization on the basis of the constructed crystal phase diagram, and performing efficient growth of the crystal of the biomacromolecule. Also disclosed is an apparatus for implementing the method.

公开(公告)号：US07819973B2

公开(公告)日：2010-10-26

申请号：US11471545

申请日：2006-06-21

申请人： Nobuo Niimura ,  Yuki Onishi ,  Shigeki Arai ,  Toshiyuki Chatake ,  Mitsuru Maeda ,  Kazuo Kurihara

发明人： Nobuo Niimura ,  Yuki Onishi ,  Shigeki Arai ,  Toshiyuki Chatake ,  Mitsuru Maeda ,  Kazuo Kurihara

IPC分类号： C30B29/58

CPC分类号： C30B7/00 ,  C30B29/58 ,  Y10T117/10 ,  Y10T117/1012

摘要： A method comprising the steps of continuously changing the concentrations in solution of a biomacromolecule to be crystallized and a precipitant, thereby constructing a crystal phase diagram containing a solubility curve, searching for optimum conditions of crystallization on the basis of the constructed crystal phase diagram, and performing efficient growth of the crystal of the biomacromolecule. Also disclosed is an apparatus for implementing the method.

摘要翻译： 一种包括以下步骤的方法：连续地改变要结晶的生物大分子的溶液中的浓度和沉淀剂，从而构建含有溶解度曲线的结晶相图，基于构造的晶体相图搜索最佳结晶条件;以及 执行生物大分子晶体的有效生长。 还公开了一种用于实现该方法的装置。