-
公开(公告)号：US20160374986A1
公开(公告)日：2016-12-29
申请号：US15260434
申请日：2016-09-09
发明人： Munekazu Iinuma
IPC分类号： A61K31/366 , A61K9/00
CPC分类号： A61K31/366 , A61K9/0053 , C07D309/32
摘要： A lifestyle disease improving drug is disclosed that enhances PPARα, δ and γ agonist activities that includes a compound having the lactone structure in accordance with the chemical formula 6-alkyl-5,6-dihydro-2H-pyran-2-one, the alkyl containing 4, 5, or 6 carbons. Methods for enhancing PPARα, γ and δ agonist activities in vertebrates or medically treating a vertebrate are disclosed. The methods include providing a composition of an active ingredient, the lifestyle disease improving drug, in a biologically acceptable medium and administering an effective amount of the composition to a vertebrate.
摘要翻译： 公开了一种生活方式改善药物，其增强PPARα，δ和γ激动剂活性，其包括具有根据化学式6-烷基-5,6-二氢-2H-吡喃-2-酮的内酯结构的化合物，烷基 含有4个，5个或6个碳。 公开了增强脊椎动物中PPARα，γ和δ激动剂活性或医学治疗脊椎动物的方法。 所述方法包括在生物可接受的培养基中提供活性成分的组合物，生活方式改善药物，并向脊椎动物施用有效量的组合物。
-
公开(公告)号：US20150087846A1
公开(公告)日：2015-03-26
申请号：US14388012
申请日：2013-03-21
发明人： Munekazu Iinuma
IPC分类号： C07D309/32
CPC分类号： A61K31/366 , A61K9/0053 , C07D309/32
摘要： A lifestyle disease improving drug that enhances PPARα, δ and γ agonist activities that includes a compound having the lactone structure in accordance with the chemical formula 6-alkyl-5,6-dihydro-2H-pyran-2-one, the alkyl containing 4, 5, or 6 carbons, and a method for synthesizing the compound. The method includes adding, stepwise, a butyllithium-hexane solution to a diisopropylamine-tetrahydrofuran solution, and then a 6-alkyltetrahydro-2H-pyran-2-one-tetrahydrofuran solution, wherein the alkyl contains 4, 5, or 6 carbons, adding a phenylselenyl choloride-tetrahydrofuran solution to produce a reaction mixture with a phenylselenide, extracting and purifying the phenylselenide, preparing a phenylselenide-tetrahydrofuran solution with the purified phenylselenide, and adding sodium bicarbonate and an aqueous hydrogen peroxide solution to the phenylselenide-tetrahydrofuran solution to produce a reaction mixture including the compound.
摘要翻译： 一种增强PPARα，δ和γ激动剂活性的生活方式改善药物，其包括具有根据化学式6-烷基-5,6-二氢-2H-吡喃-2-酮的内酯结构的化合物，含有4个 ，5或6个碳原子，以及合成该化合物的方法。 该方法包括将丁基锂 - 己烷溶液逐步加入到二异丙胺 - 四氢呋喃溶液中，然后加入6-烷基四氢-2H-吡喃-2-酮 - 四氢呋喃溶液，其中烷基含有4,5或6个碳，加入 苯基烯基氯化物 - 四氢呋喃溶液，以产生与苯基硒化物的反应混合物，萃取和纯化苯基硒化物，用纯化的苯基硒化物制备苯基硒化物 - 四氢呋喃溶液，并将碳酸氢钠和过氧化氢水溶液加入到苯基硒化物 - 四氢呋喃溶液中以产生 包括该化合物的反应混合物。
-
公开(公告)号：US09999612B2
公开(公告)日：2018-06-19
申请号：US15260434
申请日：2016-09-09
发明人： Munekazu Iinuma
IPC分类号： A61K31/366 , C07D309/32 , A61K9/00
CPC分类号： A61K31/366 , A61K9/0053 , C07D309/32
摘要： A lifestyle disease improving drug is disclosed that enhances PPARα, δ and γ agonist activities that includes a compound having the lactone structure in accordance with the chemical formula 6-alkyl-5,6-dihydro-2H-pyran-2-one, the alkyl containing 4, 5, or 6 carbons. Methods for enhancing PPARα, γ and δ agonist activities in vertebrates or medically treating a vertebrate are disclosed. The methods include providing a composition of an active ingredient, the lifestyle disease improving drug, in a biologically acceptable medium and administering an effective amount of the composition to a vertebrate.
-
公开(公告)号：US20160024041A1
公开(公告)日：2016-01-28
申请号：US14814013
申请日：2015-07-30
发明人： Munekazu Iinuma
IPC分类号： C07D309/32
CPC分类号： A61K31/366 , A61K9/0053 , C07D309/32
摘要： A lifestyle disease improving drug that enhances PPARα, δ and γ agonist activities that includes a compound having the lactone structure in accordance with the chemical formula 6-alkyl-5,6-dihydro-2H-pyran-2-one, the alkyl containing 4, 5, or 6 carbons.
摘要翻译： 一种增强PPARα，δ和γ激动剂活性的生活方式改善药物，其包括具有根据化学式6-烷基-5,6-二氢-2H-吡喃-2-酮的内酯结构的化合物，含有4个 ，5或6个碳。
-
-
-
搜索结果
4 条记录 (耗时 0.017 秒)
