公开(公告)号：US20050191357A1

公开(公告)日：2005-09-01

申请号：US10508337

申请日：2002-09-12

申请人： Yoshiaki Kawashima ,  Masuo Hosokawa ,  Hirofumi Takeuchi ,  Hiromitsu Yamamoto ,  Masaru Iwato ,  Kazuki Suhara ,  Toyokazu Yokoyama ,  Hiroyuki Tsujimoto ,  Akira Kondo ,  Tsunehiro Yoshidomi ,  Yoshiyuki Inoue ,  Hisato Eitoku ,  Naotoshi Kinoshita

发明人： Yoshiaki Kawashima ,  Masuo Hosokawa ,  Hirofumi Takeuchi ,  Hiromitsu Yamamoto ,  Masaru Iwato ,  Kazuki Suhara ,  Toyokazu Yokoyama ,  Hiroyuki Tsujimoto ,  Akira Kondo ,  Tsunehiro Yoshidomi ,  Yoshiyuki Inoue ,  Hisato Eitoku ,  Naotoshi Kinoshita

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/51 ,  A61K31/00 ,  B01J2/10

CPC分类号： A61K9/0075 ,  A61K9/143 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/167 ,  A61K31/00 ,  B01J2/10

摘要： A strong pressure and a strong shearing force are exerted to a mixture, constituted of two kinds or more of powder materials including a drug powder, while causing the mixture to pass between a press section (26) of a press head (24) and a receiving surface (25) of a cylindrical rotator (23), thereby combining the drug powder with the other powder material. For example, at least one of a drug and a biocompatible polymer is made into a nano particle whose average particle diameter is less than 1000 nm, and the nano particle is made into a composite in accordance with a dry mechanical particle combining method, so as to form a polymer nano composite particle. Thus, it is possible to produce a composite particle, which contains a drug under a stable condition, in a short time, and it is possible to remarkably improve its handling property without losing advantages of the nano particle. As a result, it is possible to favorably apply the foregoing technique to DDS of a powdery drug taken into the body through the lung or a similar drug.

摘要翻译： 在由压粉头（24）的压榨部（26）和压头（24）的压入部（26）之间通过的情况下，对由包含药物粉末的粉末材料构成的混合物施加强大的压力和强的剪切力， 圆柱形旋转器（23）的接收表面（25），从而将药物粉末与其它粉末材料组合。 例如，将药物和生物相容性聚合物中的至少一种制成平均粒径小于1000nm的纳米粒子，根据干燥机械粒子组合法将纳米粒子制成复合体， 以形成聚合物纳米复合颗粒。 因此，可以在短时间内制造含有稳定状态的药物的复合粒子，并且可以显着提高其处理性能而不损失纳米粒子的优点。 结果，可以有利地将上述技术应用于通过肺或类似药物摄入体内的粉末状药物的DDS。

公开(公告)号：US06695238B2

公开(公告)日：2004-02-24

申请号：US10091118

申请日：2002-03-06

申请人： Masahiro Inoki ,  Tsunehiro Yoshidomi

发明人： Masahiro Inoki ,  Tsunehiro Yoshidomi

IPC分类号： B02C1906

CPC分类号： F26B5/06 ,  F26B5/065

摘要： Liquid material is caused to freeze as a molded frozen body in a cylindrical form after the shape of the tubular inner wall surface of the freeze-drying apparatus, wherein the moisture content of the molded frozen material is sublimated under the vacuum to freeze-dry the material in the apparatus. A discharge port is defined at the lower end side of the tube, and jet nozzles are disposed, in the inner wall surface of the tube, for ejecting compressed air or gas toward the inner bore of the tube. The molded frozen body of the liquid material as freeze-dried is crushed and pulverized within the tube, by jet current ejected from jet nozzles.

摘要翻译： 在冷冻干燥装置的管状内壁表面形状之后，将液体材料冷冻成为圆筒状的模制冷冻体，其中模制冷冻材料的水分含量在真空下升华以冷冻干燥 设备中的材料。 排出口被限定在管的下端侧，并且在管的内壁表面中设置喷嘴以将压缩空气或气体朝向管的内孔排出。 冷冻干燥的液体材料的模制冷冻体通过从喷嘴喷射的射流被粉碎并在管内粉碎。