公开(公告)号：US06881866B2

公开(公告)日：2005-04-19

申请号：US10615297

申请日：2003-07-09

申请人： Kinji Kato ,  Tsuyoshi Hatakeyama ,  Mitsuharu Kitamura

发明人： Kinji Kato ,  Tsuyoshi Hatakeyama ,  Mitsuharu Kitamura

IPC分类号： C07B61/00 ,  C07C45/49 ,  C07C47/542

CPC分类号： C07C45/49 ,  C07C47/542

摘要： In the process of the present invention, a polyalkyl-substituted aromatic aldehyde is produced by the formylation of a corresponding polyalkyl-substituted aromatic compound with carbon monoxide in the presence of hydrogen fluoride/boron trifluoride catalyst. By limiting the amount of hydrogen fluoride to a specific range, the formylation rapidly proceeds under mild conditions without causing the precipitation of solid matters even when the starting polyalkyl-substituted aromatic compound has alkyl groups on both the carbon atoms adjacent to the site to be formylated.

摘要翻译： 在本发明的方法中，通过在氟化氢/三氟化硼催化剂的存在下，用一氧化碳将相应的聚烷基取代的芳族化合物甲酰化来制备聚烷基取代的芳族醛。 通过将氟化氢的量限制到特定范围，甲酰化在温和条件下快速进行，而不引起固体物质的沉淀，即使起始多烷基取代的芳族化合物在与要甲酰化的位点相邻的碳原子上具有烷基 。

公开(公告)号：US07154008B2

公开(公告)日：2006-12-26

申请号：US10963572

申请日：2004-10-14

申请人： Kinji Kato ,  Yoshihiro Shiokawa ,  Tsuyoshi Hatakeyama ,  Mitsuharu Kitamura

发明人： Kinji Kato ,  Yoshihiro Shiokawa ,  Tsuyoshi Hatakeyama ,  Mitsuharu Kitamura

IPC分类号： C07C45/49

CPC分类号： C07C45/49 ,  C07C47/542

摘要： In the production of an alkylbenzaldehyde by a method comprising a step of preparing a solution of complex of a starting alkylbenzene and a hydrogen fluoride-boron trifluoride catalyst and a step of formylation by bringing the solution of complex into contact with carbon monoxide, an alkylbenzene having at least one primary alkyl group having two or more carbon atoms on its benzene ring is used as the starting alkylbenzene. The preparation of the solution of complex is carried out in the presence of an aliphatic or alicyclic saturated hydrocarbon having 6 to 10 carbon atoms which contains at least one tertiary carbon atom but contains no quaternary carbon atom. By the combined use of the specific alkylbenzene and the aliphatic or alicyclic saturated hydrocarbon, the disproportionation of the alkylbenzene is prevented and the alkylbenzaldehyde is produced at high yields.

摘要翻译： 在通过包括以下步骤的方法制备烷基苯甲醛时，所述方法包括通过使配合物溶液与一氧化碳接触来制备起始烷基苯和氟化氢 - 三氟化硼催化剂的络合物的溶液的步骤和甲酰化步骤， 在其苯环上具有至少一个具有两个或更多个碳原子的伯烷基用作起始烷基苯。 络合物溶液的制备在含有至少一个叔碳原子但不含有季碳原子的含有6至10个碳原子的脂族或脂环族饱和烃的存在下进行。 通过组合使用特定的烷基苯和脂族或脂环族饱和烃，可以防止烷基苯的歧化，并以高产率生产烷基苯甲醛。

公开(公告)号：US20050085670A1

公开(公告)日：2005-04-21

申请号：US10963572

申请日：2004-10-14

申请人： Kinji Kato ,  Yoshihiro Shiokawa ,  Tsuyoshi Hatakeyama ,  Mitsuharu Kitamura

发明人： Kinji Kato ,  Yoshihiro Shiokawa ,  Tsuyoshi Hatakeyama ,  Mitsuharu Kitamura

IPC分类号： C07B61/00 ,  C07C45/49 ,  C07C47/542

CPC分类号： C07C45/49 ,  C07C47/542

摘要： In the production of an alkylbenzaldehyde by a method comprising a step of preparing a solution of complex of a starting alkylbenzene and a hydrogen fluoride-boron trifluoride catalyst and a step of formylation by bringing the solution of complex into contact with carbon monoxide, an alkylbenzene having at least one primary alkyl group having two or more carbon atoms on its benzene ring is used as the starting alkylbenzene. The preparation of the solution of complex is carried out in the presence of an aliphatic or alicyclic saturated hydrocarbon having 6 to 10 carbon atoms which contains at least one tertiary carbon atom but contains no quaternary carbon atom. By the combined use of the specific alkylbenzene and the aliphatic or alicyclic saturated hydrocarbon, the disproportionation of the alkylbenzene is prevented and the alkylbenzaldehyde is produced at high yields.

摘要翻译： 在通过包括以下步骤的方法制备烷基苯甲醛时，所述方法包括通过使配合物溶液与一氧化碳接触来制备起始烷基苯和氟化氢 - 三氟化硼催化剂的络合物的溶液的步骤和甲酰化步骤， 在其苯环上具有至少一个具有两个或更多个碳原子的伯烷基用作起始烷基苯。 络合物溶液的制备在含有至少一个叔碳原子但不含有季碳原子的含有6至10个碳原子的脂族或脂环族饱和烃的存在下进行。 通过组合使用特定的烷基苯和脂族或脂环族饱和烃，可以防止烷基苯的歧化，并以高产率生产烷基苯甲醛。