公开(公告)号：US12263177B2

公开(公告)日：2025-04-01

申请号：US17428812

申请日：2020-02-06

Applicant: UNIVERSIDAD CENTRAL DEL CARIBE ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Michelle M. Martinez-Montemayor ,  Fatima Rivas

IPC: A61K31/575 ,  A61K36/074 ,  A61K47/20 ,  A61P35/00 ,  G01N33/58

Abstract: The bioactive compounds of Ganoderma lucidum extract (GLE) responsible for anticancer activity were elucidated using NMR, X-ray crystallography and analogue derivatization, as well as anti-cancer activity studies. Structures of the seven most abundant GLE compounds are disclosed. Their selective efficacy against triple negative (TNBC) and inflammatory breast cancers (IBC) and other human cancer cell types (solid and blood malignancies) was shown, confirming potential their as anticancer agents.

公开(公告)号：US20220125805A1

公开(公告)日：2022-04-28

申请号：US17428812

申请日：2020-02-06

Applicant: UNIVERSIDAD CENTRAL DEL CARIBE ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Michelle M. MARTINEZ-MONTEMAYOR ,  Fatima RIVAS

IPC: A61K31/575 ,  A61K36/074 ,  A61K47/20 ,  A61P35/00 ,  G01N33/58

Abstract: The bioactive compounds of Ganoderma lucidum extract (GLE) responsible for anticancer activity were elucidated using NMR, X-ray crystallography and analogue derivatization, as well as anti-cancer activity studies. Structures of the seven most abundant GLE compounds are disclosed. Their selective efficacy against triple negative (TNBC) and inflammatory breast cancers (IBC) and other human cancer cell types (solid and blood malignancies) was shown, confirming potential their as anticancer agents.