公开(公告)号：US20220178929A1

公开(公告)日：2022-06-09

申请号：US17441386

申请日：2020-03-23

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSSTRY COOPERATION ,  THE ASAN FOUNDATION

Inventor： Kyung Jin LEE ,  Sin HWANG

IPC: G01N33/574 ,  G01N33/533 ,  C12N5/16 ,  C12P21/00 ,  C07K16/18

Abstract: Provided are the use of cereblon (CRBN) as a biomarker for diagnosis of hepatocellular carcinoma and novel monoclonal antibodies specific to CRBN. More specifically, provided are a composition and a kit for diagnosing or predicting the prognosis of hepatocellular carcinoma by using CRBN as a biomarker for diagnosis of hepatocellular carcinoma, an information providing method for diagnosing or predicting the prognosis of hepatocellular carcinoma, two novel monoclonal antibodies binding specifically to CRBN, and hybridoma cells producing the same. The expression level difference of CRBN protein allows patients with hepatocellular carcinoma to be diagnosed early and indicates better predictive capabilities than the presence or absence of microvascular invasion, which was an important factor in predicting a prognosis of hepatocellular carcinoma in prior art, and thus can be expected to be used as a diagnostic marker to diagnose hepatocellular carcinoma and to evaluate a prognosis after hepatic resection.