公开(公告)号：US06830932B1

公开(公告)日：2004-12-14

申请号：US09762691

申请日：2001-02-09

申请人： Oliver Danne ,  Ulrich Frei ,  Adolf Zschunke ,  Clemens Mügge

发明人： Oliver Danne ,  Ulrich Frei ,  Adolf Zschunke ,  Clemens Mügge

IPC分类号： G01N3300

CPC分类号： G01N33/92 ,  Y10S436/811

摘要： The invention relates to an in vitro method of recognizing acute coronary syndroms, especially an acute myocardial infarction, by determining and evaluating the content of choline, choline and/or trimethyl ammonium derivatives selected from the group comprising phosphoryl choline, plasmalogens, and lysoplasmenyl choline, and/or the reaction products thereof selected from the group comprising 1-O-alk-1′-enyl-2 substituted glycerol and 1-O-alk-1′-enyl-2 substituted glycerol phosphate in body fluids or component parts of the body, said method comprising the following steps: drawing a sample of a suitable body fluid or component part of the body; determining the content of choline, choline and/or trimethyl ammonium derivatives selected from the group comprising phosphoryl choline, plasmalogens, and lysoplasmenyl choline, and/or the reaction products thereof selected from the group comprising 1-O-alk-1′-enyl-2 substituted glycerol and 1-O-alk-1′-enyl-2 substituted glycerol phosphate by a suitable method of determination (nuclear magnetic resonance methods, biochemical, enzymatic, immunological, clinical-chemical, chromatographic, mass spectrometric, electrochemical, photometric methods, or other methods); and evaluating the measured results, taking into account a limit value for recognition or exclusion of acute coronary syndroms, especially an acute myocardial infarction.

摘要翻译： 本发明涉及通过确定和评估选自磷酸胆碱，血浆原和溶血素胆碱的胆碱，胆碱和/或三甲基铵衍生物的含量来鉴定急性冠状动脉综合征，特别是急性心肌梗塞的体外方法， 和/或其选自包含1-O-烷基-1'-烯基-2取代的甘油和1-O-烷基-1'-烯基-2取代的甘油磷酸酯的反应产物在体液或组分部分 所述方法包括以下步骤：绘制身体的合适体液或组分部分的样品; 确定选自磷酸胆碱，血浆原和血清素胆碱的胆碱，胆碱和/或三甲基铵衍生物的含量，和/或其选自包含1-O-烷基-1'-烯基 - 2取代甘油和1-O-烷基-1'-烯基-2取代的甘油磷酸酯通过合适的测定方法（核磁共振法，生物化学，酶学，免疫学，临床化学，色谱，质谱，电化学，光度法 ，或其他方法）; 并评估测量结果，同时考虑到识别或排除急性冠状动脉综合征，特别是急性心肌梗死的极限值。