公开(公告)号：US20090099375A1

公开(公告)日：2009-04-16

申请号：US11989621

申请日：2006-07-20

申请人： Vipin Kumar Kaushik ,  Umar Khan Mohammed ,  Sivakumaran Meenakshisunderam

发明人： Vipin Kumar Kaushik ,  Umar Khan Mohammed ,  Sivakumaran Meenakshisunderam

IPC分类号： C07D307/81

CPC分类号： C07D307/87

摘要： The present invention relates to an improved process for the preparation of Escitalopram of the Formula (I), which comprises, isolation of Diol compound as an oxalate salt, resolution of Diol compound and cyclization of resolved compound of Formula (VII). The present invention provides a process to obtain pure Diol compound by preparing its Oxalate salt, which is useful for resolution of enantiomers.

摘要翻译： 本发明涉及一种制备式（I）的依他普仑的改进方法，其包括分离作为草酸盐的二醇化合物，二醇化合物的拆分和式（VII）的拆分化合物的环化。 本发明提供通过制备其草酸盐来获得纯二醇化合物的方法，其可用于拆分对映异构体。

公开(公告)号：US07939680B2

公开(公告)日：2011-05-10

申请号：US11989621

申请日：2006-07-20

申请人： Vipin Kumar Kaushik ,  Umar Khan Mohammed ,  Sivakumaran Meenakshisunderam

发明人： Vipin Kumar Kaushik ,  Umar Khan Mohammed ,  Sivakumaran Meenakshisunderam

IPC分类号： C07D307/00

CPC分类号： C07D307/87

摘要： The present invention relates to an improved process for the preparation of Escitalopram of the Formula (I), which comprises, isolation of Diol compound as an oxalate salt, resolution of Diol compound and cyclization of resolved compound of Formula (VII). The present invention provides a process to obtain pure Diol compound by preparing its Oxalate salt, which is useful for resolution of enantiomers.

摘要翻译： 本发明涉及一种制备式（I）的依他普仑的改进方法，其包括分离作为草酸盐的二醇化合物，二醇化合物的拆分和式（VII）的拆分化合物的环化。 本发明提供通过制备其草酸盐来获得纯二醇化合物的方法，其可用于拆分对映异构体。