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公开(公告)号：US11471430B2
公开(公告)日：2022-10-18
申请号：US17261255
申请日：2019-07-17
IPC分类号： A61K31/167 , A61K31/133 , A61K31/164
摘要： Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.
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公开(公告)号：US20210275473A1
公开(公告)日：2021-09-09
申请号：US17261255
申请日：2019-07-17
IPC分类号： A61K31/167 , A61K31/133 , A61K31/164
摘要： Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.
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3.发明申请USE OF SPHINGOID LONG CHAIN BASES AND THEIR ANALOGS IN TREATING AND PREVENTING BACTERIAL INFECTIONS 审中-公开刺激长链基因及其类似物在治疗和预防细菌感染中的应用公开(公告)号：US20150258043A1
公开(公告)日：2015-09-17
申请号：US14435848
申请日：2013-10-15
IPC分类号： A61K31/133 , A61K31/7028 , A61K9/00 , A61K31/225 , A61K31/661 , A61K31/662 , A61K31/137 , A61K31/164
CPC分类号： A61K31/133 , A61K9/0073 , A61K31/137 , A61K31/164 , A61K31/225 , A61K31/661 , A61K31/662 , A61K31/7028 , C07F9/091 , C07F9/3808
摘要： Methods of preventing or treating bacterial infections, including but not limited to Pseudomonas aeruginosa infections, by administering sphingoid long chain bases (LCB) are provided. The invention further relates to the use of sphingoid long chain bases, or pharmaceutical composition comprising same, for the treatment of lung diseases or disorders such as cystic fibrosis and chronic obstructive pulmonary disease.
摘要翻译： 提供了通过给予鞘氨醇类长链碱基（LCB）预防或治疗细菌感染的方法，包括但不限于铜绿假单胞菌感染。 本发明进一步涉及鞘氨醇类长链碱基或包含其的药物组合物用于治疗肺部疾病或病症如囊性纤维化和慢性阻塞性肺疾病的用途。
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