公开(公告)号：US20110045004A1

公开(公告)日：2011-02-24

申请号：US12808821

申请日：2008-12-22

申请人： Andreas Radbruch ,  Uwe Niesner ,  Inka Albrecht ,  Hyun-Dong Chang ,  Torsten Stamm ,  Joachim Gruen ,  Andreas Gruetzkau

发明人： Andreas Radbruch ,  Uwe Niesner ,  Inka Albrecht ,  Hyun-Dong Chang ,  Torsten Stamm ,  Joachim Gruen ,  Andreas Gruetzkau

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/566 ,  C07H21/02 ,  A61K38/02 ,  A61P29/00

CPC分类号： G01N33/56972 ,  G01N33/505 ,  G01N2800/24

摘要： The invention relates to a method for in-vitro detecting pathogenic T helper cells by incubating a sample of a body fluid or tissue taken from a mammal with substances specifically interacting with at least one gene product encoded by selected genes, which are differentially expressed compared to normal T helper cells, determining specific incubation products, correlating an amount of signal or change in signal with a concentration of the gene product in the sample, and detecting cell pathogenicity by comparing the concentration with another gene product concentration in a sample of non-pathogenic and/or pathogenic cells. Another object if the invention concerns a pharmaceutical composition for prophylaxis and therapy of chronicinflammatory. The invention also relates to a method for screening substances with the property to reduce the pathogenicity of T helper cells along with the symptoms of chronic inflammatory diseases.

摘要翻译： 本发明涉及一种用于体外检测病原性T辅助细胞的方法，该方法通过将取自哺乳动物的体液或组织的样品与与所选基因编码的至少一种基因产物特异性相互作用的物质进行体外检测，所述基因产物与 正常T辅助细胞，确定特异性孵育产物，将信号量或信号变化与样品中基因产物的浓度相关联，并通过将浓度与非致病性样品中的另一种基因产物浓度进行比较来检测细胞致病性 和/或致病细胞。 如果本发明涉及用于预防和治疗慢性炎症的药物组合物，另一个目的。 本发明还涉及一种用于筛选具有降低T辅助细胞致病性的性质以及慢性炎性疾病症状的物质的方法。