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公开(公告)号：US20240165176A1
公开(公告)日：2024-05-23
申请号：US18520513
申请日：2023-11-27
发明人： Jiang LI , Yinghan SU
IPC分类号： A61K35/761 , A61K38/19 , A61K38/20 , A61K38/21 , A61P35/00
CPC分类号： A61K35/761 , A61K38/195 , A61K38/208 , A61K38/217 , A61P35/00 , C12N2710/10022 , C12N2710/10032
摘要： Provided are chimeric oncolytic adenoviruses simultaneously expressing IL-12, IFN-γ, and CCL5, and an application thereof in tumor treatment. A capsid protein hexon of the oncolytic adenovirus is formed from chimerizing hexon sequences of the two serotype viruses Ad5 and Ad48, and a fiber protein is formed from chimerizing fiber sequences of the two serotype viruses Ad5 and Ad11. The chimeric oncolytic adenovirus can activate intrinsic anti-cancer activity of a variety of viral structural proteins, the ability to infect tumor cells is increased while also ensuring that the virus itself avoids interception from pre-existing neutralizing antibodies and adhesion and uptake of hepatocytes, and an effect of killing cancer cells is enhanced.
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公开(公告)号：US20220235332A1
公开(公告)日：2022-07-28
申请号：US17615163
申请日：2020-01-02
发明人： Yinghan Su
摘要： A fast and accurate three-plasmid oncolytic adenovirus recombinant packaging system Ad5MixPlus and an application thereof are provided. The system is composed of three adenovirus recombinant plasmids. The core technology of the system is that two sets of different site recombination sequences are skillfully loaded on a first 5-type adenovirus right arm backbone plasmid large vector, then two small shuttle plasmids respectively provide a right arm-modified Hexon/E3/Fiber sequence and an E1a expression cassette controlled by a left arm tumor-specific promoter, and the difficulties and obstacles to the modification of the adenovirus backbone large vector are overcome. After two rounds of site-specific recombination, the ideal oncolytic adenovirus is packaged accurately and quickly.
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